1. Direct control of CSF pulsatility and its effect on CBF: initial findings using a novel method and device
- Author
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Stephen M. Dombrowski, Serge El Khoury, Natalie Krajcir, Mark G. Luciano, and Jun Yang
- Subjects
CSF PRESSURE ,business.industry ,Direct control ,Blood flow ,lcsh:RC346-429 ,Compliance (physiology) ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Cerebral blood flow ,Neurology ,Medicine ,Oral Presentation ,business ,Neuroscience ,lcsh:Neurology. Diseases of the nervous system - Abstract
Background Over the past several years, there has been newly emerging and overlapping fields of research investigating CSF pressure and flow pulsatility (CSFp), and cerebral blood flow (CBF). It is not known whether CSFp is merely a passive epiphenomena or alternatively, plays a physiologically significant role in cerebral compliance and blood flow. Thus, the relationship between CSFp and CBF is not clearly understood. In order to study the effect of CSF pulsatility on blood flow, we have developed a novel method and device for controlling (i.e., reducing or augmenting) pulsatility.
- Published
- 2010