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Your search keyword '"Yuanyi Feng"' showing total 3 results
Start Over Author "Yuanyi Feng" Journal cellular immunology
3 results on '"Yuanyi Feng"'

1. High K

Author

Balamurugan, Packialakshmi, Sharanpreet, Hira, Yuanyi, Feng, David W, Scott, Jason R, Lees, and Xiaoming, Zhou

Subjects
Mice, Inbred C57BL, Mice, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Animals, Th17 Cells, T-Lymphocytes, Regulatory
Abstract

Multiple sclerosis is believed to be triggered by the interplay between the environmental and genetic factors. In contrast to the Paleolithic diet, the modern Western diet is high in Na

Published
2022

2. NFAT5 contributes to the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and decrease of T regulatory cells in female mice

Author

Balamurugan Packialakshmi, Sharanpreet Hira, Kateryna Lund, Ai-Hong Zhang, Julia Halterman, Yuanyi Feng, David W. Scott, Jason R. Lees, and Xiaoming Zhou

Subjects
Mice, Inbred C57BL, Mice, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Immunology, Animals, Humans, Female, T-Lymphocytes, Regulatory, Spleen, Transcription Factors
Abstract

Multiple sclerosis disproportionally affects women. The present study was undertaken to determine whether NFAT5 contributed to the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, and if it did, whether the impact was sex associated. NFAT5 haplodeficiency reduced the disease severity only in female mice. This effect was associated with significant increases in frequency of T regulatory (Treg) cells in the CNS (from 1.45 ± 0.39% to 3.73 ± 0.94%) and spleen from (0.31 ± 0.06% to 0.94 ± 0.29%) without significantly affecting the CNS CD4

Published
2022

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