6 results on '"TAAR1"'
Search Results
2. The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats
- Author
-
Nikita Bortnikov, A. Dorotenko, M. A. Tur, Irina V Belozertseva, Edwin Zvartau, I. Sukhanov, Raul R. Gainetdinov, and Antonina Dolgorukova
- Subjects
Male ,0301 basic medicine ,Agonist ,medicine.drug_class ,Affect (psychology) ,Impulsivity ,Receptors, G-Protein-Coupled ,Executive Function ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,TAAR1 ,medicine ,Animals ,Rats, Wistar ,Receptor ,Oxazoles ,Dose-Response Relationship, Drug ,business.industry ,Cognitive flexibility ,Cell Biology ,General Medicine ,Executive functions ,Rats ,030104 developmental biology ,Action (philosophy) ,Conditioning, Operant ,medicine.symptom ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Trace amine-associated receptor 1 (TAAR1) is a widely recognized new perspective target for the neuropsychiatric pharmacological treatment. Despite a growing number of studies investigating TAAR1 role in the animal models of different pathologies, information of TAAR1 agonists impact on executive cognitive functions is limited. The goal of the present study was to evaluate the activity of highly selective partial TAAR1 agonist RO5263397 on various executive cognitive functions. The results of the present study demonstrated that the pretreatment with RO5263397 was able to increase attention and decrease cognitive flexibility in rats. The analysis of the RO5263397 action on impulsivity demonstrated that the TAAR1 activation failed to affect premature responding but was able to slightly modify impulsive choice. Problem solving was resistant to the pharmacological intervention.
- Published
- 2019
3. Molecular Variants in Human Trace Amine-Associated Receptors and Their Implications in Mental and Metabolic Disorders
- Author
-
Grazia Rutigliano and Riccardo Zucchi
- Subjects
Bipolar disorder ,Cell Cycle Proteins ,Genetics ,Schizophrenia ,Single nucletide polymorphism ,Trace amine-associated receptors ,Single-nucleotide polymorphism ,Biology ,Receptors, G-Protein-Coupled ,TAAR6 ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Metabolic Diseases ,TAAR1 ,medicine ,Animals ,Humans ,Receptor ,Trace amine ,Trace amine-associated receptor ,Original Research ,030304 developmental biology ,Genetic association ,0303 health sciences ,Mental Disorders ,Genetic Variation ,Cell Biology ,General Medicine ,medicine.disease ,030217 neurology & neurosurgery - Abstract
We provide a comprehensive review of the available evidence on the pathophysiological implications of genetic variants in the human trace amine-associated receptor (TAAR) superfamily. Genes coding for trace amine-associated receptors (taars) represent a multigene family of G-protein-coupled receptors, clustered to a small genomic region of 108 kb located in chromosome 6q23, which has been consistently identified by linkage analyses as a susceptibility locus for schizophrenia and affective disorders. Most TAARs are expressed in brain areas involved in emotions, reward and cognition. TAARs are activated by endogenous trace amines and thyronamines, and evidence for a modulatory action on other monaminergic systems has been reported. Therefore, linkage analyses were followed by fine mapping association studies in schizophrenia and affective disorders. However, none of these reports has received sufficient universal replication, so their status remains uncertain. Single nucleotide polymorphisms intaarshave emerged as susceptibility loci from genome-wide association studies investigating migraine and brain development, but none of the detected variants reached the threshold for genome-wide significance. In the last decade, technological advances enabled single-gene or whole-exome sequencing, thus allowing the detection of rare genetic variants, which may have a greater impact on the risk of complex disorders. Using these approaches, severaltaars(especiallytaar1) variants have been detected in patients with mental and metabolic disorders, and in some cases, defective receptor function has been demonstrated in vitro. Finally, with the use of transcriptomic and peptidomic techniques, dysregulations of TAARs (especially TAAR6) have been identified in brain disorders characterized by cognitive impairment.
- Published
- 2019
4. Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice
- Author
-
I. V. Karpova, S. G. Dagayev, Raul R. Gainetdinov, Alena Kozlova, E. L. Sinitca, I. Y. Tissen, V. A. Kashuro, Ilya S. Zhukov, L. G. Kubarskaya, and O. L. Vlasova
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Mice, 129 Strain ,Spherocytosis ,Anxiety ,Sodium Chloride ,Receptors, G-Protein-Coupled ,Mice ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,TAAR1 ,Internal medicine ,Animals ,Medicine ,Receptor ,Mice, Knockout ,Hematology ,Dose-Response Relationship, Drug ,medicine.diagnostic_test ,business.industry ,Thyroid ,Age Factors ,Erythrocyte fragility ,Complete blood count ,Cell Biology ,General Medicine ,medicine.disease ,Mice, Inbred C57BL ,030104 developmental biology ,medicine.anatomical_structure ,Endocrinology ,Knockout mouse ,business ,030217 neurology & neurosurgery - Abstract
Since the discovery in 2001, the G protein-coupled trace amine-associated receptor 1 (TAAR1) has become an important focus of research targeted on evaluation of its role in the central nervous system (CNS). Meanwhile, impact of TAAR1 in the peripheral organs is less investigated. Expression of TAAR1 was demonstrated in different peripheral tissues: pancreatic β-cells, stomach, intestines, white blood cells (WBC), and thyroid. However, the role of TAAR1 in regulation of hematological parameters has not been investigated yet. In this study, we performed analysis of anxiety-related behaviors, a complete blood count (CBC), erythrocyte fragility, as well as FT3/FT4 thyroid hormones levels in adult and middle-aged TAAR1 knockout mice. Complete blood count analysis was performed on a Siemens Advia 2120i hematology analyzer and included more than 35 measured and calculated parameters. Erythrocyte fragility test evaluated spherocytosis pathologies of red blood cells (RBC). No significant alterations in essentially all these parameters were found in mice without TAAR1. However, comparative aging analysis has revealed a decreased neutrophils level in the middle-aged TAAR1 knockout mouse group. Minimal alterations in these parameters observed in TAAR1 knockout mice suggest that future TAAR1-based therapies should exert little hematological effect and thus will likely have a good safety profile.
- Published
- 2019
5. Actions of Trace Amines in the Brain-Gut-Microbiome Axis via Trace Amine-Associated Receptor-1 (TAAR1)
- Author
-
Sahar El Aidy, Dulce Pamela González, Neva Olliffe, Marissa Puzan, Rachel Hoffing, Haley Oller, Katlynn Bugda Gwilt, and Gregory M. Miller
- Subjects
0301 basic medicine ,Bioinformatics ,Trace amine associated receptor 1 ,Receptors, G-Protein-Coupled ,Pathogenesis ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,TAAR1 ,medicine ,Animals ,Humans ,Intestinal Mucosa ,Receptor ,Gastrointestinal tract ,business.industry ,Mental Disorders ,Brain ,Cell Biology ,General Medicine ,medicine.disease ,“Gut-brain-axis” ,Inflammatory Bowel Diseases ,Gut microbiome ,Gastrointestinal Microbiome ,Trace (semiology) ,Gastrointestinal Tract ,030104 developmental biology ,Schizophrenia ,Trace amines ,Microbiome ,business ,030217 neurology & neurosurgery - Abstract
Trace amines and their primary receptor, Trace Amine-Associated Receptor-1 (TAAR1) are widely studied for their involvement in the pathogenesis of neuropsychiatric disorders despite being found in the gastrointestinal tract at physiological levels. With the emergence of the "brain-gut-microbiome axis," we take the opportunity to review what is known about trace amines in the brain, the defined sources of trace amines in the gut, and emerging understandings on the levels of trace amines in various gastrointestinal disorders. Similarly, we discuss localization of TAAR1 expression in the gut, novel findings that TAAR1 may be implicated in inflammatory bowel diseases, and the reported comorbidities of neuropsychiatric disorders and gastrointestinal disorders. With the emergence of TAAR1 specific compounds as next-generation therapeutics for schizophrenia (Roche) and Parkinson's related psychoses (Sunovion), we hypothesize a therapeutic benefit of these compounds in clinical trials in the brain-gut-microbiome axis, as well as a potential for thoughtful manipulation of the brain-gut-microbiome axis to modulate symptoms of neuropsychiatric disease.
- Published
- 2019
6. The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats.
- Author
-
Dorotenko A, Tur M, Dolgorukova A, Bortnikov N, Belozertseva IV, Zvartau EE, Gainetdinov RR, and Sukhanov I
- Subjects
- Animals, Conditioning, Operant drug effects, Conditioning, Operant physiology, Dose-Response Relationship, Drug, Male, Rats, Rats, Wistar, Executive Function drug effects, Executive Function physiology, Oxazoles pharmacology, Receptors, G-Protein-Coupled agonists, Receptors, G-Protein-Coupled physiology
- Abstract
Trace amine-associated receptor 1 (TAAR1) is a widely recognized new perspective target for the neuropsychiatric pharmacological treatment. Despite a growing number of studies investigating TAAR1 role in the animal models of different pathologies, information of TAAR1 agonists impact on executive cognitive functions is limited. The goal of the present study was to evaluate the activity of highly selective partial TAAR1 agonist RO5263397 on various executive cognitive functions. The results of the present study demonstrated that the pretreatment with RO5263397 was able to increase attention and decrease cognitive flexibility in rats. The analysis of the RO5263397 action on impulsivity demonstrated that the TAAR1 activation failed to affect premature responding but was able to slightly modify impulsive choice. Problem solving was resistant to the pharmacological intervention.
- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.