1. The Beta3 Adrenergic Receptor in Healthy and Pathological Cardiovascular Tissues.
- Author
-
Michel LYM, Farah C, and Balligand JL
- Subjects
- Animals, Antioxidants metabolism, Cardiovascular Diseases metabolism, Cardiovascular System metabolism, Catecholamines metabolism, Gene Expression Profiling, Heart Failure metabolism, Humans, Protein Isoforms, Signal Transduction, Adipocytes, Beige metabolism, Gene Expression Regulation, Myocardium metabolism, Receptors, Adrenergic, beta-3 chemistry, Receptors, Adrenergic, beta-3 metabolism
- Abstract
The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after the observation of its expression in white and beige human adipocytes and its implication in metabolic regulation. This coincides with the recent development and marketing of agonists at the human receptor with superior specificity. Twenty years ago, however, we and others described the expression of β3-AR in human myocardium and its regulation of contractility and cardiac remodeling. Subsequent work from many laboratories has since expanded the characterization of β3-AR involvement in many aspects of cardiovascular physio(patho)logy, justifying the present effort to update current paradigms under the light of the most recent evidence.
- Published
- 2020
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