1. Lamina Associated Domains and Gene Regulation in Development and Cancer.
- Author
-
Lochs SJA, Kefalopoulou S, and Kind J
- Subjects
- Animals, DNA Methylation genetics, Humans, Embryonic Development genetics, Gene Expression Regulation, Developmental, Gene Expression Regulation, Neoplastic, Neoplasms genetics, Nuclear Lamina metabolism
- Abstract
The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowly transcribed, and enriched for repressive histone modifications. LADs are dynamic structures that shift spatial positioning in accordance with cell-type specific gene expression changes during differentiation and development. Furthermore, recent studies have linked the disruption of LADs and alterations in the epigenome with the onset of diseases such as cancer. Here we focus on the role of LADs and the NL in gene regulation during development and cancer., Competing Interests: The authors declare no conflict of interest.
- Published
- 2019
- Full Text
- View/download PDF