1. The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer.
- Author
-
Hammouda MB, Ford AE, Liu Y, and Zhang JY
- Subjects
- Humans, Signal Transduction, JNK Mitogen-Activated Protein Kinases metabolism, Neoplasms genetics, Skin Diseases genetics
- Abstract
The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.
- Published
- 2020
- Full Text
- View/download PDF