1. MicroRNA-Assisted Hormone Cell Signaling in Colorectal Cancer Resistance
- Author
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Lucia Altucci, Giulia Sgueglia, Elham Safadeh, Crescenzo Massaro, Carmela Dell'Aversana, Hendrik G. Stunnenberg, Massaro, C., Safadeh, E., Sgueglia, G., Stunnenberg, H. G., Altucci, L., and Dell'Aversana, C.
- Subjects
Cell signaling ,Colorectal cancer ,hormone signaling ,colorectal cancer ,Disease ,Drug resistance ,Review ,Gene expression ,microRNA ,Biomarkers, Tumor ,Medicine ,Animals ,Humans ,lcsh:QH301-705.5 ,drug resistance ,business.industry ,Cancer ,General Medicine ,medicine.disease ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,lcsh:Biology (General) ,Drug Resistance, Neoplasm ,Cancer research ,business ,Colorectal Neoplasms ,Hormone ,Signal Transduction - Abstract
Despite substantial progress in cancer therapy, colorectal cancer (CRC) is still the third leading cause of cancer death worldwide, mainly due to the acquisition of resistance and disease recurrence in patients. Growing evidence indicates that deregulation of hormone signaling pathways and their cross-talk with other signaling cascades inside CRC cells may have an impact on therapy resistance. MicroRNAs (miRNAs) are small conserved non-coding RNAs thatfunction as negative regulators in many gene expression processes. Key studies have identified miRNA alterations in cancer progression and drug resistance. In this review, we provide a comprehensive overview and assessment of miRNAs role in hormone signaling pathways in CRC drug resistance and their potential as future targets for overcoming resistance to treatment.
- Published
- 2021