1. Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions
- Author
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Véronique Baud and Davi Collares
- Subjects
NF-kappaB ,RelB ,post-translational modifications ,cell motility ,phosphorylation ,ubiquitination ,SUMOylation ,NF-κB alternative pathway ,Cytology ,QH573-671 - Abstract
The family of NF-κB transcription factors plays a key role in diverse biological processes, such as inflammatory and immune responses, cell survival and tumor development. Beyond the classical NF-κB activation pathway, a second NF-κB pathway has more recently been uncovered, the so-called alternative NF-κB activation pathway. It has been shown that this pathway mainly controls the activity of RelB, a member of the NF-κB family. Post-translational modifications, such as phosphorylation, acetylation, methylation, ubiquitination and SUMOylation, have recently emerged as a strategy for the fine-tuned regulation of NF-κB. Our review discusses recent progress in the understanding of RelB regulation by post-translational modifications and the associated functions in normal and pathological conditions.
- Published
- 2016
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