Search

Your search keyword '"Aisling Minard"' showing total 2 results
Start Over Author "Aisling Minard" Journal cells
2 results on '"Aisling Minard"'

1. Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease

Author

Aisling Minard, Claudia C. Bauer, David J. Wright, Hussein N. Rubaiy, Katsuhiko Muraki, David J. Beech, and Robin S. Bon

Subjects
ion channel, TRPC, small molecules, calcium, chemical probes, Cytology, QH573-671
Abstract

Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5. We review evidence for the formation of different TRPC1/4/5 tetramers, give an overview of recently developed small-molecule TRPC1/4/5 activators and inhibitors, highlight examples of biological roles of TRPC1/4/5 channels in different tissues and pathologies, and discuss how high-quality chemical probes of TRPC1/4/5 modulators can be used to understand the involvement of TRPC1/4/5 channels in physiological and pathophysiological processes.

Published
2018
Full Text
View/download PDF

2. Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease

Author

Claudia C. Bauer, Robin S. Bon, Hussein N. Rubaiy, Katsuhiko Muraki, David J. Beech, Aisling Minard, and David J. Wright

Subjects
0301 basic medicine, Gene isoform, calcium, TRPC, Chemistry, Review, General Medicine, TRPC5, TRPC4, Small molecule, 3. Good health, TRPC1, 03 medical and health sciences, small molecules, 030104 developmental biology, chemical probes, lcsh:Biology (General), ion channel, Biophysics, lcsh:QH301-705.5, Ion channel
Abstract

Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5. We review evidence for the formation of different TRPC1/4/5 tetramers, give an overview of recently developed small-molecule TRPC1/4/5 activators and inhibitors, highlight examples of biological roles of TRPC1/4/5 channels in different tissues and pathologies, and discuss how high-quality chemical probes of TRPC1/4/5 modulators can be used to understand the involvement of TRPC1/4/5 channels in physiological and pathophysiological processes.

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results