1. A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation
- Author
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Wang, Ling-Jia, Kin, Tatsuya, O'gorman, Doug, Shapiro, AM James, Naziruddin, Bashoo, Takita, Morihito, Levy, Marlon F, Posselt, Andrew M, Szot, Gregory L, Savari, Omid, Barbaro, Barbara, McGarrigle, James, Yeh, Chun Chieh, Oberholzer, Jose, Lei, Ji, Chen, Tao, Lian, Moh, Markmann, James F, Alvarez, Alejandro, Linetsky, Elina, Ricordi, Camillo, Balamurugan, AN, Loganathan, Gopalakrishnan, Wilhelm, Joshua J, Hering, Bernhard J, Bottino, Rita, Trucco, Massimo, Liu, Chengyang, Min, Zaw, Li, Yanjing, Naji, Ali, Fernandez, Luis A, Ziemelis, Martynas, Danobeitia, Juan S, Millis, J Michael, and Witkowski, Piotr
- Subjects
Transplantation ,Diabetes ,Clinical Research ,Adolescent ,Adult ,Aged ,Child ,Child ,Preschool ,Female ,Humans ,Islets of Langerhans Transplantation ,Male ,Middle Aged ,Pancreas ,Retrospective Studies ,Tissue Donors ,Young Adult ,Islet isolation ,Islet transplantation ,Organ donor ,Pancreas ,Biological Sciences ,Technology ,Medical and Health Sciences ,Neurology & Neurosurgery - Abstract
Selection of an optimal donor pancreas is the first key task for successful islet isolation. We conducted a retrospective multicenter study in 11 centers in North America to develop an islet donor scoring system using donor variables. The data set consisting of 1,056 deceased donors was used for development of a scoring system to predict islet isolation success (defined as postpurification islet yield >400,000 islet equivalents). With the aid of univariate logistic regression analyses, we developed the North American Islet Donor Score (NAIDS) ranging from 0 to 100 points. The c index in the development cohort was 0.73 (95% confidence interval 0.70-0.76). The success rate increased proportionally as the NAIDS increased, from 6.8% success in the NAIDS
- Published
- 2016