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1. Caught in the antiviral crossfire: Ganciclovir-associated mutagenesis in HSC transplant recipients.

Author

Spencer Chapman M and Nangalia J

Subjects
Antiviral Agents pharmacology, Antiviral Agents therapeutic use, Ganciclovir pharmacology, Ganciclovir therapeutic use, Hematopoietic Stem Cells, Humans, Mutagenesis genetics, Transplant Recipients, Cytomegalovirus Infections drug therapy, Hematopoietic Stem Cell Transplantation
Abstract

In this issue of Cell Stem Cell, de Kanter et al. (2021) show that most allogeneic hematopoietic stem cells do not acquire additional somatic mutations following transplantation. However, they observe somatic mutagenesis associated with the antiviral drug ganciclovir and find plausible evidence that it may contribute to some post-transplant malignancies., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Published
2021
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