1. A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer
- Author
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Lui Ng, Leonard Wing-Hong Cheung, Wai Lun Law, Benjamin C. Y. Wong, Colin S.C. Lam, Andrew C.Y. Chu, Ariel K.M. Chow, Hui Y. Lan, Thomas Yau, Ronnie Tung-Ping Poon, Xiao R. Lan, Victoria P.Y. Tan, J. T. C. Poon, and Roberta Pang
- Subjects
Organoplatinum Compounds ,Colorectal cancer ,Dipeptidyl Peptidase 4 ,Apoptosis ,CELLCYCLE ,Mice, SCID ,Biology ,Metastasis ,Mice ,Cancer stem cell ,Biomarkers, Tumor ,Tumor Cells, Cultured ,Genetics ,Adjuvant therapy ,medicine ,Animals ,Humans ,Neoplasm Invasiveness ,RNA, Small Interfering ,Gene Expression Profiling ,Carcinoma ,Liver Neoplasms ,Cancer ,Cell Biology ,Prognosis ,medicine.disease ,STEMCELL ,Primary tumor ,Tumor Burden ,Oxaliplatin ,Cell Transformation, Neoplastic ,Drug Resistance, Neoplasm ,Cancer cell ,Disease Progression ,Neoplastic Stem Cells ,Cancer research ,Molecular Medicine ,Fluorouracil ,Stem cell ,Cell Migration Assays ,Colorectal Neoplasms ,Neoplasm Transplantation ,Follow-Up Studies - Abstract
Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation of CD26(+) cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver metastasis. Furthermore, in patients without distant metastasis at the time of presentation, the presence of CD26(+) cells in their primary tumors predicted distant metastasis on follow-up. Isolated CD26(+) cells, but not CD26(-) cells, led to development of distant metastasis when injected into the mouse cecal wall. CD26(+) cells were also associated with enhanced invasiveness and chemoresistance. Our findings have uncovered a critical role of CSCs in metastatic progression of cancer. Furthermore, the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy.
- Published
- 2010
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