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Barrier properties of the choroid plexus (ChP) help protect the brain from the external world. In Science, Pellegrini et al. (2020) report the successful creation of human ChP organoids, which produce a cerebrospinal fluid-like secretion and recapitulate barrier functions, thereby inspiring new advances for targeted brain therapeutics., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Adult neural stem cells reside in specialized niches that maintain neurogenesis, but the components of the niche and its secretome are only partially understood. In this issue of Cell Stem Cell, Silva-Vargas et al. (2016) show that choroid plexus, within the lateral ventricles of the adult brain, secretes signals that regulate adult neurogenesis in an age-dependent manner., (Copyright © 2016 Elsevier Inc. All rights reserved.)

In this issue of Cell Stem Cell, Kokovay et al. uncover that VCAM1 expression in neural stem cells regulates adult neurogenesis. Cerebrospinal fluid-borne IL-1β upregulates VCAM1 expression, which in turn regulates the architecture of the stem cell niche, redox homeostasis, and neurogenesis., (Copyright © 2012 Elsevier Inc. All rights reserved.)