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Your search keyword '"Niu, Yuyu"' showing total 6 results
Start Over Author "Niu, Yuyu" Journal cell research
6 results on '"Niu, Yuyu"'

1. Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination

Author

Cui, Yiqiang, primary, Niu, Yuyu, additional, Zhou, Jiankui, additional, Chen, Yongchang, additional, Cheng, Yiwei, additional, Li, Shangang, additional, Ai, Zongyong, additional, Chu, Chu, additional, Wang, Hong, additional, Zheng, Bo, additional, Chen, Xuejin, additional, Sha, Jiahao, additional, Guo, Xuejiang, additional, Huang, Xingxu, additional, and Ji, Weizhi, additional

Published
2018
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2. De novo DNA methylation during monkey pre-implantation embryogenesis

Author

Gao, Fei, primary, Niu, Yuyu, additional, Sun, Yi Eve, additional, Lu, Hanlin, additional, Chen, Yongchang, additional, Li, Siguang, additional, Kang, Yu, additional, Luo, Yuping, additional, Si, Chenyang, additional, Yu, Juehua, additional, Li, Chang, additional, Sun, Nianqin, additional, Si, Wei, additional, Wang, Hong, additional, Ji, Weizhi, additional, and Tan, Tao, additional

Published
2017
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5. Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys.

Author

Chen, Yongchang, Cui, Yiqiang, Shen, Bin, Niu, Yuyu, Zhao, Xiaoyang, Wang, Lei, Wang, Jianying, Li, Wei, Zhou, Qi, Ji, Weizhi, Sha, Jiahao, and Huang, Xingxu

Subjects
CRISPRS, PRIMATE genomes, MUTAGENESIS, ANIMAL disease models, POLYMERASE chain reaction
Abstract

The article focuses on the use of endonucleases such as Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) for bringing gene modification in monkeys and generating human disease models. It states that mutagenesis was performed in several tissues of the monkeys including heart, liver and spleen, and several methods such as Polymerase Chain Reaction (PCR), polymerase chain reaction and sequencing, were used to analyze the mutagenesis.

Published
2015
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6. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system.

Author

Wan, Haifeng, Feng, Chunjing, Teng, Fei, Yang, Shihua, Hu, Baoyang, Niu, Yuyu, Xiang, Andy Peng, Fang, Weizhen, Ji, Weizhi, Li, Wei, Zhao, Xiaoyang, and Zhou, Qi

Subjects
PRIMATE genomes, CRISPRS, ANIMAL mutation, PRIMATE genetics, NUCLEASES, NUCLEOTIDES
Abstract

The article focuses on the use of site-specific nucleases such as Transcription Activator-Like Effector Nucleases (TALENs) and Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) for carrying out genome modification in non-human primates (NHPs). It states that p53 tumor suppressor gene, injected via a zygote injection using a CRISPR system, was used to produce biallelic mutant monkeys. It states that addition of desired template DNA to the CRISPR system can modify nucleotide.

Published
2015
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