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Your search keyword '"Belmonte, Juan Carlos Izpisua"' showing total 31 results
Start Over Author "Belmonte, Juan Carlos Izpisua" Journal cell research
31 results on '"Belmonte, Juan Carlos Izpisua"'

1. Single-cell transcriptomic atlas of primate cardiopulmonary aging

Author

Ma, Shuai, Sun, Shuhui, Li, Jiaming, Fan, Yanling, Qu, Jing, Sun, Liang, Wang, Si, Zhang, Yiyuan, Yang, Shanshan, Liu, Zunpeng, Wu, Zeming, Zhang, Sheng, Wang, Qiaoran, Zheng, Aihua, Duo, Shuguang, Yu, Yang, Belmonte, Juan Carlos Izpisua, Chan, Piu, Zhou, Qi, Song, Moshi, Zhang, Weiqi, and Liu, Guang-Hui

Published
2021
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4. Single-cell transcriptomic atlas of primate cardiopulmonary aging

Author

Ma, Shuai, primary, Sun, Shuhui, additional, Li, Jiaming, additional, Fan, Yanling, additional, Qu, Jing, additional, Sun, Liang, additional, Wang, Si, additional, Zhang, Yiyuan, additional, Yang, Shanshan, additional, Liu, Zunpeng, additional, Wu, Zeming, additional, Zhang, Sheng, additional, Wang, Qiaoran, additional, Zheng, Aihua, additional, Duo, Shuguang, additional, Yu, Yang, additional, Belmonte, Juan Carlos Izpisua, additional, Chan, Piu, additional, Zhou, Qi, additional, Song, Moshi, additional, Zhang, Weiqi, additional, and Liu, Guang-Hui, additional

Published
2020
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5. Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration

Author

Liang, Chuqian, primary, Liu, Zunpeng, additional, Song, Moshi, additional, Li, Wei, additional, Wu, Zeming, additional, Wang, Zehua, additional, Wang, Qiaoran, additional, Wang, Si, additional, Yan, Kaowen, additional, Sun, Liang, additional, Hishida, Tomoaki, additional, Cai, Yanning, additional, Belmonte, Juan Carlos Izpisua, additional, Guillen, Pedro, additional, Chan, Piu, additional, Zhou, Qi, additional, Zhang, Weiqi, additional, Qu, Jing, additional, and Liu, Guang-Hui, additional

Published
2020
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8. Regeneration: making muscle from hPSCs

Author

Zhu, Xiping, primary, Fu, Lina, additional, Yi, Fei, additional, Liu, Guang-Hui, additional, Ocampo, Alejandro, additional, Qu, Jing, additional, and Belmonte, Juan Carlos Izpisua, additional

Published
2014
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11. “TET-on” pluripotency

Author

Wang, Ping, primary, Qu, Jing, additional, Wu, Min-Zu, additional, Zhang, Weizhou, additional, Liu, Guang-Hui, additional, and Belmonte, Juan Carlos Izpisua, additional

Published
2013
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24. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

Author

Panopoulos, Athanasia D, primary, Yanes, Oscar, additional, Ruiz, Sergio, additional, Kida, Yasuyuki S, additional, Diep, Dinh, additional, Tautenhahn, Ralf, additional, Herrerías, Aída, additional, Batchelder, Erika M, additional, Plongthongkum, Nongluk, additional, Lutz, Margaret, additional, Berggren, W Travis, additional, Zhang, Kun, additional, Evans, Ronald M, additional, Siuzdak, Gary, additional, and Belmonte, Juan Carlos Izpisua, additional

Published
2011
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26. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming.

Author

Panopoulos, Athanasia D, Yanes, Oscar, Ruiz, Sergio, Kida, Yasuyuki S, Diep, Dinh, Tautenhahn, Ralf, Herrerías, Aída, Batchelder, Erika M, Plongthongkum, Nongluk, Lutz, Margaret, Berggren, W Travis, Zhang, Kun, Evans, Ronald M, Siuzdak, Gary, and Belmonte, Juan Carlos Izpisua

Subjects
PLURIPOTENT stem cells, SOMATIC cells, BIOENERGETICS, CELL respiration, METABOLIC regulation
Abstract

Metabolism is vital to every aspect of cell function, yet the metabolome of induced pluripotent stem cells (iPSCs) remains largely unexplored. Here we report, using an untargeted metabolomics approach, that human iPSCs share a pluripotent metabolomic signature with embryonic stem cells (ESCs) that is distinct from their parental cells, and that is characterized by changes in metabolites involved in cellular respiration. Examination of cellular bioenergetics corroborated with our metabolomic analysis, and demonstrated that somatic cells convert from an oxidative state to a glycolytic state in pluripotency. Interestingly, the bioenergetics of various somatic cells correlated with their reprogramming efficiencies. We further identified metabolites that differ between iPSCs and ESCs, which revealed novel metabolic pathways that play a critical role in regulating somatic cell reprogramming. Our findings are the first to globally analyze the metabolome of iPSCs, and provide mechanistic insight into a new layer of regulation involved in inducing pluripotency, and in evaluating iPSC and ESC equivalence. [ABSTRACT FROM AUTHOR]

Published
2012
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27. Beating in a dish: new hopes for cardiomyocyte regeneration.

Author

Gu, Ying, Yi, Fei, Liu, Guang-Hui, and Belmonte, Juan Carlos Izpisua

Subjects
HEART cells, REGENERATION (Biology), CELL transplantation, CELL differentiation, STEM cells
Abstract

Functional human cardiomyocytes hold great promise in cell transplantation-based therapy to treat many heart diseases. To meet this devastating and clinical need, researchers are infatuated with developing novel technologies and methodologies to efficiently generate cardiomyocytes through either stem cell differentiation or cell lineage transdifferentiation. Though exciting progress has been made, challenges remain to be addressed before the translation from bench side to bed side can be fulfilled. [ABSTRACT FROM AUTHOR]

Published
2013
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28. In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK).

Author

Masuda, Shigeo, Li, Mo, and Belmonte, Juan Carlos Izpisua

Subjects
BLOOD platelets, DIRECT conversion receivers, BLOOD transfusion, BLOOD donors, PLURIPOTENT stem cells, MEGAKARYOCYTES, FIBROBLASTS
Abstract

Blood transfusion medicine requires a constant supply of platelets, which is now totally donor dependent. Recent advances in the generation of platelets in vitro through megakaryocytes (MKs) may provide protocols not only via pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), but also via induced MKs (iMKs). For the first time, mouse and human fibroblasts are successfully transdifferentiated into iMKs by the introduction of three factors, p45NF-E2, Maf G, and Maf K. [ABSTRACT FROM AUTHOR]

Published
2013
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29. The dawn of angiogenesis modeling: regenerating vasculature from human pluripotent stem cells.

Author

Yi, Fei, Qu, Jing, Liu, Guang-Hui, and Belmonte, Juan Carlos Izpisua

Subjects
NEOVASCULARIZATION, BLOOD vessels, PLURIPOTENT stem cells, VASCULAR endothelial cells, SMOOTH muscle, STEM cells
Abstract

Efficient generation of functional human vascular endothelial cells and smooth muscle cells from pluripotent stem cells is an extensively studied topic and of great interest in the stem cell field. Though thought to be technically complex and difficult, substantial progress has been made towards this direction. Here we aim to summarize and discuss the most recent advances in this topic and their future perspective in research and clinic. [ABSTRACT FROM AUTHOR]

Published
2013
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30. Regenerative medicine: Transdifferentiation in vivo.

Author

Fu, Lina, Zhu, Xiping, Yi, Fei, Liu, Guang-Hui, and Belmonte, Juan Carlos Izpisua

Subjects
REGENERATIVE medicine, FERTILIZATION in vitro, CELL differentiation, CELL determination, CELL transplantation, INDUCED pluripotent stem cells
Abstract

A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and cost-effective alternative for applications in regenerative medicine and may also minimize the concerns associated with in vitro culture and cell transplantation. [ABSTRACT FROM AUTHOR]

Published
2014
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31. Cut and Paste: restoring cellular function by gene correction.

Author

Liu, Guang-Hui, Sancho-Martinez, Ignacio, and Belmonte, Juan Carlos Izpisua

Subjects
CYTOLOGICAL research, GENES, PLURIPOTENT stem cells, STEM cells, PARKINSON'S disease, THALASSEMIA, SICKLE cell anemia
Abstract

The article presents research related to the restoration of cellular function by gene correction. It is stated that gene correction technologies may lead to the precise excision of mutant genes responsible for monogenic disease. Recently, many research groups have demonstrated the successful generation and correction of patient-specific induced pluripotent stem cells (iPSCs). These include the progeria syndrome, Parkinson's disease, thalassemia, and sickle cell anemia.

Published
2012
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