Search

During tumorigenesis, the recently identified tumor-specific memory T cells in draining lymph nodes (TdLN-TTSMcells) play a pivotal role in tumor repression that gives rise to progenitor exhausted T (TPEX) cells and further replenishes tumor-specific CD8+T cells residing in the tumor microenvironment (TME). However, how TTSMcells are maintained in TdLN is largely unknown. Here, we show that the transcription regulator ID3 (inhibitor of DNA binding 3) is highly expressed by TTSMcells compared with other CD8+T cell subsets. The deficiency of ID3 significantly interrupts the maintenance of TTSMand TPEXcells, resulting in decreased tumor-infiltrating CD8+T cells and impaired tumor control. Consistent with this, overexpression of ID3 in CD8+T cells increases the TTSMcell population and enhances the anti-tumor immune response.