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2 results on '"Tonti, E"'

1. Bisphosphonates Target B Cells to Enhance Humoral Immune Responses

Author

Gabriele Galliverti, E. Ashley Moseman, Luigi Gennari, Laura Sironi, Nicolas Chevrier, Nereida Jiménez de Oya, Stefano Sammicheli, Matteo Iannacone, Luca G. Guidotti, Marco De Giovanni, Angelo Amabile, Pietro Di Lucia, Ulrich H. von Andrian, Elena Tonti, Giovanni Sitia, Tonti, E, Jiménez de Oya, N, Galliverti, G, Moseman, E, Di Lucia, P, Amabile, A, Sammicheli, S, De Giovanni, M, Sironi, L, Chevrier, N, Sitia, G, Gennari, L, Guidotti, L, von Andrian, U, Iannacone, M, Jimenez de Oya, N, Moseman, Ea, Guidotti, Lg, and von Andrian, Uh

Subjects
Inflammasomes, GERMINAL CENTER FORMATION, SUBCAPSULAR SINUS MACROPHAGES, BEARING DENDRITIC CELLS, T-CELLS, LYMPH-NODE, ACTIVATION, INFECTION, RECEPTOR, VIRUS, ANTIGEN, Immunoglobulin G, Mice, 0302 clinical medicine, Receptor, lcsh:QH301-705.5, Adjuvant, B-Lymphocytes, Mice, Inbred BALB C, 0303 health sciences, Diphosphonates, biology, Toll-Like Receptors, B-Lymphocyte, Bisphosphonates, 3. Good health, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Signal transduction, Hapten, Signal Transduction, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Immune system, Adjuvants, Immunologic, Antigen, Immunity, medicine, Animals, Humans, B cell, 030304 developmental biology, Vesiculovirus, Immunity, Humoral, Mice, Inbred C57BL, lcsh:Biology (General), Antibody Formation, Immunology, biology.protein
Abstract

Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients. We show here that the administration of clinically relevant doses of bisphosphonates in mice increases antibody responses to live and inactive viruses, proteins, haptens and existing commercial vaccine formulations. Bisphosphonates exert this adjuvant-like activity in the absence of CD4+ and γδ T cells, neutrophils or dendritic cells and their effect does not rely on local macrophage depletion nor does it depend upon Toll-like receptor signaling or the inflammasome. Rather, bisphosphonates target directly B cells and enhance B cell expansion and antibody production upon antigen encounter. These data establish bisphosphonates as a novel class of adjuvants that boost humoral immune responses.

Published
2013
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2. Bisphosphonates target B cells to enhance humoral immune responses.

Author

Tonti E, Jiménez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, and Iannacone M

Subjects
Adjuvants, Immunologic, Animals, Antibody Formation drug effects, B-Lymphocytes drug effects, B-Lymphocytes immunology, Humans, Immunoglobulin G metabolism, Inflammasomes metabolism, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Signal Transduction, Toll-Like Receptors metabolism, Vesiculovirus immunology, B-Lymphocytes metabolism, Diphosphonates pharmacology, Immunity, Humoral drug effects
Abstract

Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients. We show here that the administration of clinically relevant doses of bisphosphonates in mice increases antibody responses to live and inactive viruses, proteins, haptens, and existing commercial vaccine formulations. Bisphosphonates exert this adjuvant-like activity in the absence of CD4(+) and γδ T cells, neutrophils, or dendritic cells, and their effect does not rely on local macrophage depletion, Toll-like receptor signaling, or the inflammasome. Rather, bisphosphonates target directly B cells and enhance B cell expansion and antibody production upon antigen encounter. These data establish bisphosphonates as an additional class of adjuvants that boost humoral immune responses., (Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2013
Full Text
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