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5 results on '"Simeone, Antonio"'

2. Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons

Author

Kim, Hyoung-Tai, Kim, Soung Jung, Sohn, Young-In, Paik, Sun-Sook, Caplette, Romain, Simonutti, Manuel, Moon, Kyeong Hwan, Lee, Eun Jung, Min, Kwang Wook, Kim, Mi Jeong, Lee, Dong-Gi, Simeone, Antonio, Lamonerie, Thomas, Furukawa, Takahisa, Choi, Jong-Soon, Kweon, Hee-Seok, Picaud, Serge, Kim, In-Beom, Shong, Minho, and Kim, Jin Woo

Published
2015
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3. The H3K27 Demethylase JMJD3 Is Required for Maintenance of the Embryonic Respiratory Neuronal Network, Neonatal Breathing, and Survival

Author

Burgold, Thomas, Voituron, Nicolas, Caganova, Marieta, Tripathi, Prem Prakash, Menuet, Clement, Tusi, Betsabeh Khoramian, Spreafico, Fabio, Bévengut, Michelle, Gestreau, Christian, Buontempo, Serena, Simeone, Antonio, Kruidenier, Laurens, Natoli, Gioacchino, Casola, Stefano, Hilaire, Gérard, and Testa, Giuseppe

Published
2012
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5. Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast

Author

Daniela Omodei, Antonio Simeone, Luca Giovanni Di Giovannantonio, Marco Savarese, Giuseppe Petrosino, Vincenzo Mercadante, Dario Acampora, Vincenzo Nigro, Arcomaria Garofalo, Acampora, Dario, Omodei, Daniela, Petrosino, Giuseppe, Garofalo, Arcomaria, Savarese, Marco, Nigro, Vincenzo, DI GIOVANNANTONIO, Luca Giovanni, Mercadante, Vincenzo, and Simeone, Antonio

Subjects
0301 basic medicine, Homeobox protein NANOG, Rex1, Embryonic Development, Biology, Nanog, Leukemia Inhibitory Factor, General Biochemistry, Genetics and Molecular Biology, Mesoderm, 03 medical and health sciences, Mice, SOX2, Inner cell mass, Animals, Cell Lineage, Binding site, Promoter Regions, Genetic, lcsh:QH301-705.5, reproductive and urinary physiology, Embryonic Stem Cells, Cell Proliferation, Biochemistry, Genetics and Molecular Biology (all), Binding Sites, Otx Transcription Factors, Chimera, Gene Expression Profiling, Endoderm, Gene Expression Regulation, Developmental, Cell Differentiation, Nanog Homeobox Protein, pluripotency, Molecular biology, Embryonic stem cell, Cell biology, preimplantation epiblast, Cell Compartmentation, 030104 developmental biology, Blastocyst, lcsh:Biology (General), Epiblast, embryonic structures, Mutation, Stem cell, biological phenomena, cell phenomena, and immunity, Germ Layers, Otx2, Protein Binding
Abstract

SummaryMouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluripotency. ESC-derived epiblast stem cells (EpiSCs) and the postimplantation epiblast exhibit primed pluripotency. Although core pluripotency factors are well-characterized, additional regulators, including Otx2, recently have been shown to function during the transition from naive to primed pluripotency. Here we uncover a role for Otx2 in the control of the naive pluripotent state. We analyzed Otx2-binding activity in ESCs and EpiSCs and identified Nanog, Oct4, and Sox2 as direct targets. To unravel the Otx2 transcriptional network, we targeted the strongest Otx2-binding site in the Nanog promoter, finding that this site modulates the size of specific ESC-subtype compartments in cultured cells and promotes Nanog expression in vivo, predisposing ICM differentiation to epiblast. Otx2-mediated Nanog regulation thus contributes to the integrity of the ESC state and cell lineage specification in preimplantation development.

Published
2016
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