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Your search keyword '"Shunsuke Ohori"' showing total 2 results
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2 results on '"Shunsuke Ohori"'

1. Targeted Delivery of Immunomodulators to Lymph Nodes

Author

Jamil Azzi, Qian Yin, Mayuko Uehara, Shunsuke Ohori, Li Tang, Kaimin Cai, Takaharu Ichimura, Martina McGrath, Omar Maarouf, Eirini Kefaloyianni, Scott Loughhead, Jarolim Petr, Qidi Sun, Mincheol Kwon, Stefan Tullius, Ulrich H. von Andrian, Jianjun Cheng, and Reza Abdi

Subjects
Biology (General), QH301-705.5
Abstract

Active-targeted delivery to lymph nodes represents a major advance toward more effective treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node addressin molecules expressed by high endothelial venules of lymph nodes. By mimicking lymphocyte trafficking to the lymph nodes, we have engineered MECA79-coated microparticles containing an immunosuppressive medication, tacrolimus. Following intravenous administration, MECA79-bearing particles showed marked accumulation in the draining lymph nodes of transplanted animals. Using an allograft heart transplant model, we show that targeted lymph node delivery of microparticles containing tacrolimus can prolong heart allograft survival with negligible changes in tacrolimus serum level. Using MECA79 conjugation, we have demonstrated targeted delivery of tacrolimus to the lymph nodes following systemic administration, with the capacity for immune modulation in vivo.

Published
2016
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2. Targeted Delivery of Immunomodulators to Lymph Nodes

Author

Reza Abdi, Martina M. McGrath, Stefan G. Tullius, Kaimin Cai, Jamil Azzi, Ulrich H. von Andrian, Eirini Kefaloyianni, Shunsuke Ohori, Li Tang, Qidi Sun, Omar H. Maarouf, Takaharu Ichimura, Jarolim Petr, Qian Yin, Jianjun Cheng, Scott Loughhead, Mincheol Kwon, and Mayuko Uehara

Subjects
0301 basic medicine, medicine.medical_treatment, Lymphocyte, Polyesters, High endothelial venules, chemical and pharmacologic phenomena, 02 engineering and technology, General Biochemistry, Genetics and Molecular Biology, Article, Antibodies, Tacrolimus, 03 medical and health sciences, Drug Delivery Systems, Addressin, Medicine, Animals, Immunologic Factors, Lymph node, lcsh:QH301-705.5, Cell Proliferation, Heart transplantation, Mice, Inbred BALB C, biology, business.industry, Graft Survival, Membrane Proteins, 021001 nanoscience & nanotechnology, Microspheres, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, surgical procedures, operative, lcsh:Biology (General), Immunology, Antigens, Surface, biology.protein, Systemic administration, Cytokines, Heart Transplantation, Lymph, Lymph Nodes, 0210 nano-technology, business, Immunosuppressive Agents, Neoplasm Transplantation
Abstract

SUMMARY Active-targeted delivery to lymph nodes represents a major advance toward more effective treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node address in molecules expressed by high endothelial venules of lymph nodes. By mimicking lymphocyte trafficking to the lymph nodes, we have engineered MECA79-coated microparticles containing an immunosuppressive medication, tacrolimus. Following intravenous administration, MECA79-bearing particles showed marked accumulation in the draining lymph nodes of transplanted animals. Using an allograft heart transplant model, we show that targeted lymph node delivery of microparticles containing tacrolimus can prolong heart allograft survival with negligible changes in tacrolimus serum level. Using MECA79 conjugation, we have demonstrated targeted delivery of tacrolimus to the lymph nodes following systemic administration, with the capacity for immune modulation in vivo., Graphical Abstract

Published
2016
Full Text
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