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12 results on '"Rawi, Reda"'

1. Cholesterol reduction by immunization with a PCSK9 mimic

Author

Zhang, Baoshan, Chuang, Gwo-Yu, Biju, Andrea, Biner, Daniel, Cheng, Jiaxuan, Wang, Yiran, Bao, Saran, Chao, Cara W., Lei, Haotian, Liu, Tracy, Nazzari, Alexandra F., Yang, Yongping, Zhou, Tongqing, Chen, Steven J., Chen, Xuejun, Kong, Wing-Pui, Ou, Li, Parchment, Danealle K., Sarfo, Edward K., SiMa, HaoMin, Todd, John-Paul, Wang, Shuishu, Woodward, Ruth A., Cheng, Cheng, Rawi, Reda, Mascola, John R., and Kwong, Peter D.

Published
2024
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2. HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide

Author

Wang, Shuishu, Matassoli, Flavio, Zhang, Baoshan, Liu, Tracy, Shen, Chen-Hsiang, Bylund, Tatsiana, Johnston, Timothy, Henry, Amy R., Teng, I-Ting, Tripathi, Prabhanshu, Becker, Jordan E., Changela, Anita, Chaudhary, Ridhi, Cheng, Cheng, Gaudinski, Martin, Gorman, Jason, Harris, Darcy R., Lee, Myungjin, Morano, Nicholas C., Novik, Laura, O’Dell, Sijy, Olia, Adam S., Parchment, Danealle K., Rawi, Reda, Roberts-Torres, Jesmine, Stephens, Tyler, Tsybovsky, Yaroslav, Wang, Danyi, Van Wazer, David J., Zhou, Tongqing, Doria-Rose, Nicole A., Koup, Richard A., Shapiro, Lawrence, Douek, Daniel C., McDermott, Adrian B., and Kwong, Peter D.

Published
2023
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4. Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies

Author

Cottrell, Christopher A., Manne, Kartik, Kong, Rui, Wang, Shuishu, Zhou, Tongqing, Chuang, Gwo-Yu, Edwards, Robert J., Henderson, Rory, Janowska, Katarzyna, Kopp, Megan, Lin, Bob C., Louder, Mark K., Olia, Adam S., Rawi, Reda, Shen, Chen-Hsiang, Taft, Justin D., Torres, Jonathan L., Wu, Nelson R., Zhang, Baoshan, Doria-Rose, Nicole A., Cohen, Myron S., Haynes, Barton F., Shapiro, Lawrence, Ward, Andrew B., Acharya, Priyamvada, Mascola, John R., and Kwong, Peter D.

Published
2021
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5. Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains

Author

Rawi, Reda, primary, Rutten, Lucy, additional, Lai, Yen-Ting, additional, Olia, Adam S., additional, Blokland, Sven, additional, Juraszek, Jarek, additional, Shen, Chen-Hsiang, additional, Tsybovsky, Yaroslav, additional, Verardi, Raffaello, additional, Yang, Yongping, additional, Zhang, Baoshan, additional, Zhou, Tongqing, additional, Chuang, Gwo-Yu, additional, Kwong, Peter D., additional, and Langedijk, Johannes P.M., additional

Published
2020
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6. Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation

Author

Cheung, Crystal Sao-Fong, primary, Fruehwirth, Alexander, additional, Paparoditis, Philipp Carl Georg, additional, Shen, Chen-Hsiang, additional, Foglierini, Mathilde, additional, Joyce, M. Gordon, additional, Leung, Kwanyee, additional, Piccoli, Luca, additional, Rawi, Reda, additional, Silacci-Fregni, Chiara, additional, Tsybovsky, Yaroslav, additional, Verardi, Raffaello, additional, Wang, Lingshu, additional, Wang, Shuishu, additional, Yang, Eun Sung, additional, Zhang, Baoshan, additional, Zhang, Yi, additional, Chuang, Gwo-Yu, additional, Corti, Davide, additional, Mascola, John R., additional, Shapiro, Lawrence, additional, Kwong, Peter D., additional, Lanzavecchia, Antonio, additional, and Zhou, Tongqing, additional

Published
2020
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7. Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

Author

Gorman, Jason, primary, Chuang, Gwo-Yu, additional, Lai, Yen-Ting, additional, Shen, Chen-Hsiang, additional, Boyington, Jeffrey C., additional, Druz, Aliaksandr, additional, Geng, Hui, additional, Louder, Mark K., additional, McKee, Krisha, additional, Rawi, Reda, additional, Verardi, Raffaello, additional, Yang, Yongping, additional, Zhang, Baoshan, additional, Doria-Rose, Nicole A., additional, Lin, Bob, additional, Moore, Penny L., additional, Morris, Lynn, additional, Shapiro, Lawrence, additional, Mascola, John R., additional, and Kwong, Peter D., additional

Published
2020
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8. Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

Author

Wagh, Kshitij, primary, Kreider, Edward F., additional, Li, Yingying, additional, Barbian, Hannah J., additional, Learn, Gerald H., additional, Giorgi, Elena, additional, Hraber, Peter T., additional, Decker, Timothy G., additional, Smith, Andrew G., additional, Gondim, Marcos V., additional, Gillis, Lindsey, additional, Wandzilak, Jamie, additional, Chuang, Gwo-Yu, additional, Rawi, Reda, additional, Cai, Fangping, additional, Pellegrino, Pierre, additional, Williams, Ian, additional, Overbaugh, Julie, additional, Gao, Feng, additional, Kwong, Peter D., additional, Haynes, Barton F., additional, Shaw, George M., additional, Borrow, Persephone, additional, Seaman, Michael S., additional, Hahn, Beatrice H., additional, and Korber, Bette, additional

Published
2018
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9. Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

Author

Kwon, Young D., primary, Chuang, Gwo-Yu, additional, Zhang, Baoshan, additional, Bailer, Robert T., additional, Doria-Rose, Nicole A., additional, Gindin, Tatyana S., additional, Lin, Bob, additional, Louder, Mark K., additional, McKee, Krisha, additional, O’Dell, Sijy, additional, Pegu, Amarendra, additional, Schmidt, Stephen D., additional, Asokan, Mangaiarkarasi, additional, Chen, Xuejun, additional, Choe, Misook, additional, Georgiev, Ivelin S., additional, Jin, Vivian, additional, Pancera, Marie, additional, Rawi, Reda, additional, Wang, Keyun, additional, Chaudhuri, Rajoshi, additional, Kueltzo, Lisa A., additional, Manceva, Slobodanka D., additional, Todd, John-Paul, additional, Scorpio, Diana G., additional, Kim, Mikyung, additional, Reinherz, Ellis L., additional, Wagh, Kshitij, additional, Korber, Bette M., additional, Connors, Mark, additional, Shapiro, Lawrence, additional, Mascola, John R., additional, and Kwong, Peter D., additional

Published
2018
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10. Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains

Author

Joyce, M. Gordon, primary, Georgiev, Ivelin S., additional, Yang, Yongping, additional, Druz, Aliaksandr, additional, Geng, Hui, additional, Chuang, Gwo-Yu, additional, Kwon, Young Do, additional, Pancera, Marie, additional, Rawi, Reda, additional, Sastry, Mallika, additional, Stewart-Jones, Guillaume B.E., additional, Zheng, Angela, additional, Zhou, Tongqing, additional, Choe, Misook, additional, Van Galen, Joseph G., additional, Chen, Rita E., additional, Lees, Christopher R., additional, Narpala, Sandeep, additional, Chambers, Michael, additional, Tsybovsky, Yaroslav, additional, Baxa, Ulrich, additional, McDermott, Adrian B., additional, Mascola, John R., additional, and Kwong, Peter D., additional

Published
2017
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11. Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

Author

Zhou, Tongqing, primary, Doria-Rose, Nicole A., additional, Cheng, Cheng, additional, Stewart-Jones, Guillaume B.E., additional, Chuang, Gwo-Yu, additional, Chambers, Michael, additional, Druz, Aliaksandr, additional, Geng, Hui, additional, McKee, Krisha, additional, Kwon, Young Do, additional, O’Dell, Sijy, additional, Sastry, Mallika, additional, Schmidt, Stephen D., additional, Xu, Kai, additional, Chen, Lei, additional, Chen, Rita E., additional, Louder, Mark K., additional, Pancera, Marie, additional, Wanninger, Timothy G., additional, Zhang, Baoshan, additional, Zheng, Anqi, additional, Farney, S. Katie, additional, Foulds, Kathryn E., additional, Georgiev, Ivelin S., additional, Joyce, M. Gordon, additional, Lemmin, Thomas, additional, Narpala, Sandeep, additional, Rawi, Reda, additional, Soto, Cinque, additional, Todd, John-Paul, additional, Shen, Chen-Hsiang, additional, Tsybovsky, Yaroslav, additional, Yang, Yongping, additional, Zhao, Peng, additional, Haynes, Barton F., additional, Stamatatos, Leonidas, additional, Tiemeyer, Michael, additional, Wells, Lance, additional, Scorpio, Diana G., additional, Shapiro, Lawrence, additional, McDermott, Adrian B., additional, Mascola, John R., additional, and Kwong, Peter D., additional

Published
2017
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12. Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.

Author

Young D. Kwon, Gwo-Yu Chuang, Baoshan Zhang, Bailer, Robert T., Doria-Rose, Nicole A., Gindin, Tatyana S., Lin, Bob, Louder, Mark K., McKee, Krisha, O'Dell, Sijy, Pegu, Amarendra, Schmidt, Stephen D., Asokan, Mangaiarkarasi, Xuejun Chen, Misook Choe, Georgiev, Ivelin S., Jin, Vivian, Pancera, Marie, Rawi, Reda, and Keyun Wang

Abstract

Highly effective HIV-1-neutralizing antibodies could have utility in the prevention or treatment of HIV-1 infection. To improve the potency of 10E8, an antibody capable of near pan-HIV-1 neutralization, we engineered 10E8-surface mutants and screened for improved neutralization. Variants with the largest functional enhancements involved the addition of hydrophobic or positively charged residues, which were positioned to interact with viral membrane lipids orviral glycan-sialic acids, respectively. In both cases, the site of improvement was spatially separated from the region of antibody mediating molecular contact with the protein component of the antigen, thereby improving peripheral semi-specific interactions while maintaining unmodified dominant contacts responsible for broad recognition. The optimized 10E8 antibody, with mutations to phenylalanine and arginine, retained the extraordinary breadth of 10E8 but with ~10-fold increased potency. We propose surface-matrix screening as a general method to improve antibodies, with improved semi-specific interactions between antibody and antigen enabling increased potency without compromising breadth. [ABSTRACT FROM AUTHOR]

Published
2018
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