Search

Your search keyword '"Kuanwei Sheng"' showing total 2 results
Start Over Author "Kuanwei Sheng" Journal cell reports
2 results on '"Kuanwei Sheng"'

1. Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity

Author

Neus Bota-Rabassedas, Priyam Banerjee, Yichi Niu, Wenjian Cao, Jiayi Luo, Yuanxin Xi, Xiaochao Tan, Kuanwei Sheng, Young-Ho Ahn, Sieun Lee, Edwin Roger Parra, Jaime Rodriguez-Canales, Jacob Albritton, Michael Weiger, Xin Liu, Hou-Fu Guo, Jiang Yu, B. Leticia Rodriguez, Joshua J.A. Firestone, Barbara Mino, Chad J. Creighton, Luisa M. Solis, Pamela Villalobos, Maria Gabriela Raso, Daniel W. Sazer, Don L. Gibbons, William K. Russell, Gregory D. Longmore, Ignacio I. Wistuba, Jing Wang, Harold A. Chapman, Jordan S. Miller, Chenghang Zong, and Jonathan M. Kurie

Subjects
cancer-associated fibroblast, EMT, metastasis, lung cancer, tumor microenvironment, microRNA, Biology (General), QH301-705.5
Abstract

Summary: Cancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneity is driven by lung adenocarcinoma (LUAD) cells at either end of the epithelial-to-mesenchymal transition (EMT) spectrum. LUAD cells that have high expression of the EMT-activating transcription factor ZEB1 reprogram CAFs through a ZEB1-dependent secretory program and direct CAFs to the tips of invasive projections through a ZEB1-driven CAF repulsion process. The EMT, in turn, sensitizes LUAD cells to pro-metastatic signals from CAFs. Thus, CAFs respond to contextual cues from LUAD cells to promote metastasis.

Published
2021
Full Text
View/download PDF

2. Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity

Author

Barbara Mino, Young Ho Ahn, Neus Bota-Rabassedas, Edwin R. Parra, Chenghang Zong, Daniel W. Sazer, Jonathan M. Kurie, Joshua J.A. Firestone, Wenjian Cao, B. Leticia Rodriguez, Sieun Lee, Jing Wang, Priyam Banerjee, Jiayi Luo, Xiaochao Tan, Xin Liu, Luisa M. Solis, Jordan S. Miller, Jacob Albritton, Maria Gabriela Raso, Gregory D. Longmore, Pamela Villalobos, Chad J. Creighton, Hou Fu Guo, Ignacio I. Wistuba, Yichi Niu, Jiang Yu, William K. Russell, Don L. Gibbons, Yuanxin Xi, Michael Weiger, Harold A. Chapman, Jaime Rodriguez-Canales, and Kuanwei Sheng

Subjects
0301 basic medicine, Male, Lung Neoplasms, cancer-associated fibroblast, Cell Communication, Metastasis, Mice, 0302 clinical medicine, Cancer-Associated Fibroblasts, Cell Movement, Tumor Microenvironment, Biology (General), microRNA, EMT, Kidney Neoplasms, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Adenocarcinoma, Signal Transduction, Stromal cell, Epithelial-Mesenchymal Transition, QH301-705.5, Adenocarcinoma of Lung, Mice, Transgenic, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Discoidin Domain Receptor 2, Cell Line, Tumor, Alpha-Globulins, medicine, metastasis, Animals, Humans, Fibroblast, Transcription factor, Cell Proliferation, Tumor microenvironment, Gene Expression Profiling, Zinc Finger E-box-Binding Homeobox 1, Epithelial Cells, Mesenchymal Stem Cells, medicine.disease, lung cancer, 030104 developmental biology, Cancer cell, Cancer research, 030217 neurology & neurosurgery
Abstract

SUMMARY Cancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneity is driven by lung adenocarcinoma (LUAD) cells at either end of the epithelial-to-mesenchymal transition (EMT) spectrum. LUAD cells that have high expression of the EMT-activating transcription factor ZEB1 reprogram CAFs through a ZEB1-dependent secretory program and direct CAFs to the tips of invasive projections through a ZEB1-driven CAF repulsion process. The EMT, in turn, sensitizes LUAD cells to pro-metastatic signals from CAFs. Thus, CAFs respond to contextual cues from LUAD cells to promote metastasis., In brief Bota-Rabassedas et al. show that EMT in lung adenocarcinoma cells activates a secretory process that governs CAF heterogeneity and, in turn, sensitizes lung adenocarcinoma cells to pro-metastatic signals from CAFs. Thus, EMT positions lung adenocarcinoma cells at the apex of a signaling hierarchy in the tumor microenvironment., Graphical Abstract

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results