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7 results on '"Graham, Mark"'

2. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

Author

Warrier, Manya, Shih, Diana M, Burrows, Amy C, Ferguson, Daniel, Gromovsky, Anthony D, Brown, Amanda L, Marshall, Stephanie, McDaniel, Allison, Schugar, Rebecca C, Wang, Zeneng, Sacks, Jessica, Rong, Xin, de Aguiar Vallim, Thomas, Chou, Jeff, Ivanova, Pavlina T, Myers, David S, Brown, H Alex, Lee, Richard G, Crooke, Rosanne M, Graham, Mark J, Liu, Xiuli, Parini, Paolo, Tontonoz, Peter, Lusis, Aldon J, Hazen, Stanley L, Temel, Ryan E, and Brown, J Mark

Subjects
Biochemistry and Cell Biology, Biological Sciences, Liver Disease, Atherosclerosis, Nutrition, Digestive Diseases, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Good Health and Well Being, Medical Physiology, Biological sciences
Abstract

Circulating levels of the gut microbe-derived metabolite trimethylamine-N-oxide (TMAO) have recently been linked to cardiovascular disease (CVD) risk. Here, we performed transcriptional profiling in mouse models of altered reverse cholesterol transport (RCT) and serendipitously identified the TMAO-generating enzyme flavin monooxygenase 3 (FMO3) as a powerful modifier of cholesterol metabolism and RCT. Knockdown of FMO3 in cholesterol-fed mice alters biliary lipid secretion, blunts intestinal cholesterol absorption, and limits the production of hepatic oxysterols and cholesteryl esters. Furthermore, FMO3 knockdown stimulates basal and liver X receptor (LXR)-stimulated macrophage RCT, thereby improving cholesterol balance. Conversely, FMO3 knockdown exacerbates hepatic endoplasmic reticulum (ER) stress and inflammation in part by decreasing hepatic oxysterol levels and subsequent LXR activation. FMO3 is thus identified as a central integrator of hepatic cholesterol and triacylglycerol metabolism, inflammation, and ER stress. These studies suggest that the gut microbiota-driven TMA/FMO3/TMAO pathway is a key regulator of lipid metabolism and inflammation.

Published
2015

3. Circuit-selective cell-autonomous regulation of inhibition in pyramidal neurons by Ste20-like kinase

Author

Royero, Pedro, primary, Quatraccioni, Anne, additional, Früngel, Rieke, additional, Silva, Mariella Hurtado, additional, Bast, Arco, additional, Ulas, Thomas, additional, Beyer, Marc, additional, Opitz, Thoralf, additional, Schultze, Joachim L., additional, Graham, Mark E., additional, Oberlaender, Marcel, additional, Becker, Albert, additional, Schoch, Susanne, additional, and Beck, Heinz, additional

Published
2022
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4. A presynaptic phosphosignaling hub for lasting homeostatic plasticity

Author

Müller, Johannes Alexander, primary, Betzin, Julia, additional, Santos-Tejedor, Jorge, additional, Mayer, Annika, additional, Oprişoreanu, Ana-Maria, additional, Engholm-Keller, Kasper, additional, Paulußen, Isabelle, additional, Gulakova, Polina, additional, McGovern, Terrence Daniel, additional, Gschossman, Lena Johanna, additional, Schönhense, Eva, additional, Wark, Jesse R., additional, Lamprecht, Alf, additional, Becker, Albert J., additional, Waardenberg, Ashley J., additional, Graham, Mark E., additional, Dietrich, Dirk, additional, and Schoch, Susanne, additional

Published
2022
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5. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Author

Schugar, Rebecca C., primary, Shih, Diana M., additional, Warrier, Manya, additional, Helsley, Robert N., additional, Burrows, Amy, additional, Ferguson, Daniel, additional, Brown, Amanda L., additional, Gromovsky, Anthony D., additional, Heine, Markus, additional, Chatterjee, Arunachal, additional, Li, Lin, additional, Li, Xinmin S., additional, Wang, Zeneng, additional, Willard, Belinda, additional, Meng, YongHong, additional, Kim, Hanjun, additional, Che, Nam, additional, Pan, Calvin, additional, Lee, Richard G., additional, Crooke, Rosanne M., additional, Graham, Mark J., additional, Morton, Richard E., additional, Langefeld, Carl D., additional, Das, Swapan K., additional, Rudel, Lawrence L., additional, Zein, Nizar, additional, McCullough, Arthur J., additional, Dasarathy, Srinivasan, additional, Tang, W.H. Wilson, additional, Erokwu, Bernadette O., additional, Flask, Chris A., additional, Laakso, Markku, additional, Civelek, Mete, additional, Naga Prasad, Sathyamangla V., additional, Heeren, Joerg, additional, Lusis, Aldons J., additional, Hazen, Stanley L., additional, and Brown, J. Mark, additional

Published
2017
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6. Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation

Author

Lord, Caleb C., primary, Ferguson, Daniel, additional, Thomas, Gwynneth, additional, Brown, Amanda L., additional, Schugar, Rebecca C., additional, Burrows, Amy, additional, Gromovsky, Anthony D., additional, Betters, Jenna, additional, Neumann, Chase, additional, Sacks, Jessica, additional, Marshall, Stephanie, additional, Watts, Russell, additional, Schweiger, Martina, additional, Lee, Richard G., additional, Crooke, Rosanne M., additional, Graham, Mark J., additional, Lathia, Justin D., additional, Sakaguchi, Takuya F., additional, Lehner, Richard, additional, Haemmerle, Guenter, additional, Zechner, Rudolf, additional, and Brown, J. Mark, additional

Published
2016
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7. The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome

Author

Thomas, Gwynneth, primary, Betters, Jenna L., additional, Lord, Caleb C., additional, Brown, Amanda L., additional, Marshall, Stephanie, additional, Ferguson, Daniel, additional, Sawyer, Janet, additional, Davis, Matthew A., additional, Melchior, John T., additional, Blume, Lawrence C., additional, Howlett, Allyn C., additional, Ivanova, Pavlina T., additional, Milne, Stephen B., additional, Myers, David S., additional, Mrak, Irina, additional, Leber, Vera, additional, Heier, Christoph, additional, Taschler, Ulrike, additional, Blankman, Jacqueline L., additional, Cravatt, Benjamin F., additional, Lee, Richard G., additional, Crooke, Rosanne M., additional, Graham, Mark J., additional, Zimmermann, Robert, additional, Brown, H. Alex, additional, and Brown, J. Mark, additional

Published
2013
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