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Your search keyword '"Doranz, Benjamin J."' showing total 11 results
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11 results on '"Doranz, Benjamin J."'

1. Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes

Author

Sankhala, Rajeshwer S., Dussupt, Vincent, Donofrio, Gina, Gromowski, Gregory D., De La Barrera, Rafael A., Larocca, Rafael A., Mendez-Rivera, Letzibeth, Lee, Anna, Choe, Misook, Zaky, Weam, Mantus, Grace, Jensen, Jaime L., Chen, Wei-Hung, Gohain, Neelakshi, Bai, Hongjun, McCracken, Michael K., Mason, Rosemarie D., Leggat, David, Slike, Bonnie M., Tran, Ursula, Jian, Ningbo, Abbink, Peter, Peterson, Rebecca, Mendes, Erica Araujo, Freitas de Oliveira Franca, Rafael, Calvet, Guilherme Amaral, Bispo de Filippis, Ana Maria, McDermott, Adrian, Roederer, Mario, Hernandez, Mayda, Albertus, Amie, Davidson, Edgar, Doranz, Benjamin J., Rolland, Morgane, Robb, Merlin L., Lynch, Rebecca M., Barouch, Dan H., Jarman, Richard G., Thomas, Stephen J., Modjarrad, Kayvon, Michael, Nelson L., Krebs, Shelly J., and Joyce, M. Gordon

Published
2023
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2. Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes

Author

Chen, Elaine C., Gilchuk, Pavlo, Zost, Seth J., Ilinykh, Philipp A., Binshtein, Elad, Huang, Kai, Myers, Luke, Bonissone, Stefano, Day, Samuel, Kona, Chandrahaas R., Trivette, Andrew, Reidy, Joseph X., Sutton, Rachel E., Gainza, Christopher, Diaz, Summer, Williams, Jazmean K., Selverian, Christopher N., Davidson, Edgar, Saphire, Erica Ollmann, Doranz, Benjamin J., Castellana, Natalie, Bukreyev, Alexander, Carnahan, Robert H., and Crowe, James E., Jr.

Published
2023
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3. Sites of vulnerability in HCV E1E2 identified by comprehensive functional screening

Author

Pfaff-Kilgore, Jennifer M., primary, Davidson, Edgar, additional, Kadash-Edmondson, Kathryn, additional, Hernandez, Mayda, additional, Rosenberg, Erin, additional, Chambers, Ross, additional, Castelli, Matteo, additional, Clementi, Nicola, additional, Mancini, Nicasio, additional, Bailey, Justin R., additional, Crowe, James E., additional, Law, Mansun, additional, and Doranz, Benjamin J., additional

Published
2022
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4. Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition

Author

Kramer, Kevin J., primary, Johnson, Nicole V., additional, Shiakolas, Andrea R., additional, Suryadevara, Naveenchandra, additional, Periasamy, Sivakumar, additional, Raju, Nagarajan, additional, Williams, Jazmean K., additional, Wrapp, Daniel, additional, Zost, Seth J., additional, Walker, Lauren M., additional, Wall, Steven C., additional, Holt, Clinton M., additional, Hsieh, Ching-Lin, additional, Sutton, Rachel E., additional, Paulo, Ariana, additional, Nargi, Rachel S., additional, Davidson, Edgar, additional, Doranz, Benjamin J., additional, Crowe, James E., additional, Bukreyev, Alexander, additional, Carnahan, Robert H., additional, McLellan, Jason S., additional, and Georgiev, Ivelin S., additional

Published
2021
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5. Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

Author

Chen, Elaine C., primary, Gilchuk, Pavlo, additional, Zost, Seth J., additional, Suryadevara, Naveenchandra, additional, Winkler, Emma S., additional, Cabel, Carly R., additional, Binshtein, Elad, additional, Chen, Rita E., additional, Sutton, Rachel E., additional, Rodriguez, Jessica, additional, Day, Samuel, additional, Myers, Luke, additional, Trivette, Andrew, additional, Williams, Jazmean K., additional, Davidson, Edgar, additional, Li, Shuaizhi, additional, Doranz, Benjamin J., additional, Campos, Samuel K., additional, Carnahan, Robert H., additional, Thorne, Curtis A., additional, Diamond, Michael S., additional, and Crowe, James E., additional

Published
2021
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6. Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies

Author

Murin, Charles D., primary, Gilchuk, Pavlo, additional, Ilinykh, Philipp A., additional, Huang, Kai, additional, Kuzmina, Natalia, additional, Shen, Xiaoli, additional, Bruhn, Jessica F., additional, Bryan, Aubrey L., additional, Davidson, Edgar, additional, Doranz, Benjamin J., additional, Williamson, Lauren E., additional, Copps, Jeffrey, additional, Alkutkar, Tanwee, additional, Flyak, Andrew I., additional, Bukreyev, Alexander, additional, Crowe, James E., additional, and Ward, Andrew B., additional

Published
2021
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7. In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model

Author

Patel, Ami, primary, Park, Daniel H., additional, Davis, Carl W., additional, Smith, Trevor R.F., additional, Leung, Anders, additional, Tierney, Kevin, additional, Bryan, Aubrey, additional, Davidson, Edgar, additional, Yu, Xiaoying, additional, Racine, Trina, additional, Reed, Charles, additional, Gorman, Marguerite E., additional, Wise, Megan C., additional, Elliott, Sarah T.C., additional, Esquivel, Rianne, additional, Yan, Jian, additional, Chen, Jing, additional, Muthumani, Kar, additional, Doranz, Benjamin J., additional, Saphire, Erica Ollmann, additional, Crowe, James E., additional, Broderick, Kate E., additional, Kobinger, Gary P., additional, He, Shihua, additional, Qiu, Xiangguo, additional, Kobasa, Darwyn, additional, Humeau, Laurent, additional, Sardesai, Niranjan Y., additional, Ahmed, Rafi, additional, and Weiner, David B., additional

Published
2018
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8. Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus

Author

Howell, Katie A., primary, Brannan, Jennifer M., additional, Bryan, Christopher, additional, McNeal, Andrew, additional, Davidson, Edgar, additional, Turner, Hannah L., additional, Vu, Hong, additional, Shulenin, Sergey, additional, He, Shihua, additional, Kuehne, Ana, additional, Herbert, Andrew S., additional, Qiu, Xiangguo, additional, Doranz, Benjamin J., additional, Holtsberg, Frederick W., additional, Ward, Andrew B., additional, Dye, John M., additional, and Aman, M. Javad, additional

Published
2017
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9. Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

Author

Howell, Katie A., primary, Qiu, Xiangguo, additional, Brannan, Jennifer M., additional, Bryan, Christopher, additional, Davidson, Edgar, additional, Holtsberg, Frederick W., additional, Wec, Anna Z., additional, Shulenin, Sergey, additional, Biggins, Julia E., additional, Douglas, Robin, additional, Enterlein, Sven G., additional, Turner, Hannah L., additional, Pallesen, Jesper, additional, Murin, Charles D., additional, He, Shihua, additional, Kroeker, Andrea, additional, Vu, Hong, additional, Herbert, Andrew S., additional, Fusco, Marnie L., additional, Nyakatura, Elisabeth K., additional, Lai, Jonathan R., additional, Keck, Zhen-Yong, additional, Foung, Steven K.H., additional, Saphire, Erica Ollmann, additional, Zeitlin, Larry, additional, Ward, Andrew B., additional, Chandran, Kartik, additional, Doranz, Benjamin J., additional, Kobinger, Gary P., additional, Dye, John M., additional, and Aman, M. Javad, additional

Published
2016
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10. Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis

Author

Jin, Jing, primary, Liss, Nathan M., additional, Chen, Dong-Hua, additional, Liao, Maofu, additional, Fox, Julie M., additional, Shimak, Raeann M., additional, Fong, Rachel H., additional, Chafets, Daniel, additional, Bakkour, Sonia, additional, Keating, Sheila, additional, Fomin, Marina E., additional, Muench, Marcus O., additional, Sherman, Michael B., additional, Doranz, Benjamin J., additional, Diamond, Michael S., additional, and Simmons, Graham, additional

Published
2015
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11. In VivoDelivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model

Author

Patel, Ami, Park, Daniel H., Davis, Carl W., Smith, Trevor R.F., Leung, Anders, Tierney, Kevin, Bryan, Aubrey, Davidson, Edgar, Yu, Xiaoying, Racine, Trina, Reed, Charles, Gorman, Marguerite E., Wise, Megan C., Elliott, Sarah T.C., Esquivel, Rianne, Yan, Jian, Chen, Jing, Muthumani, Kar, Doranz, Benjamin J., Saphire, Erica Ollmann, Crowe, James E., Broderick, Kate E., Kobinger, Gary P., He, Shihua, Qiu, Xiangguo, Kobasa, Darwyn, Humeau, Laurent, Sardesai, Niranjan Y., Ahmed, Rafi, and Weiner, David B.

Abstract

Synthetically engineered DNA-encoded monoclonal antibodies (DMAbs) are an in vivoplatform for evaluation and delivery of human mAb to control against infectious disease. Here, we engineer DMAbs encoding potent anti-Zaire ebolavirus(EBOV) glycoprotein (GP) mAbs isolated from Ebola virus disease survivors. We demonstrate the development of a human IgG1 DMAb platform for in vivoEBOV-GP mAb delivery and evaluation in a mouse model. Using this approach, we show that DMAb-11 and DMAb-34 exhibit functional and molecular profiles comparable to recombinant mAb, have a wide window of expression, and provide rapid protection against lethal mouse-adapted EBOV challenge. The DMAb platform represents a simple, rapid, and reproducible approach for evaluating the activity of mAb during clinical development. DMAbs have the potential to be a mAb delivery system, which may be advantageous for protection against highly pathogenic infectious diseases, like EBOV, in resource-limited and other challenging settings.

Published
2018
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