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Start Over Descriptor "CA3 Region" Journal cell reports
3 results on '"CA3 Region"'

1. Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1

Author

Aery Jones, Emily A, Rao, Antara, Zilberter, Misha, Djukic, Biljana, Bant, Jason S, Gillespie, Anna K, Koutsodendris, Nicole, Nelson, Maxine, Yoon, Seo Yeon, Huang, Ky, Yuan, Heidi, Gill, Theodore M, Huang, Yadong, and Frank, Loren M

Subjects
Biological Sciences, Neurosciences, Action Potentials, Animals, CA1 Region, Hippocampal, CA3 Region, Hippocampal, Dentate Gyrus, Entorhinal Cortex, Female, GABAergic Neurons, Interneurons, Male, Mice, Mice, Inbred C57BL, Somatostatin, CA1, CA3, GABAergic interneuron, dentate gyrus, fast gamma, hippocampus, parvalbumin, sharp-wave ripple, slow gamma, somatostatin, theta, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

Specific classes of GABAergic neurons play specific roles in regulating information processing in the brain. In the hippocampus, two major classes, parvalbumin-expressing (PV+) and somatostatin-expressing (SST+), differentially regulate endogenous firing patterns and target subcellular compartments of principal cells. How these classes regulate the flow of information throughout the hippocampus is poorly understood. We hypothesize that PV+ and SST+ interneurons in the dentate gyrus (DG) and CA3 differentially modulate CA3 patterns of output, thereby altering the influence of CA3 on CA1. We find that while suppressing either interneuron class increases DG and CA3 output, the effects on CA1 were very different. Suppressing PV+ interneurons increases local field potential signatures of coupling from CA3 to CA1 and decreases signatures of coupling from entorhinal cortex to CA1; suppressing SST+ interneurons has the opposite effect. Thus, DG and CA3 PV+ and SST+ interneurons bidirectionally modulate the flow of information through the hippocampal circuit.

Published
2021

2. Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model.

Author

Jones, Emily A, Gillespie, Anna K, Yoon, Seo Yeon, Frank, Loren M, and Huang, Yadong

Subjects
Hippocampus, Animals, Mice, Alzheimer Disease, Memory Disorders, Disease Models, Animal, Risk Factors, Learning, Apolipoprotein E4, CA3 Region, Hippocampal, Spatial Memory, Biomarkers, Alzheimer’s disease, CA3, apolipoprotein E4, biomarker, hippocampus, learning, memory, sharp-wave ripple, slow gamma, Biomarker, Biochemistry and Cell Biology, Medical Physiology
Abstract

Alzheimer's disease (AD) is characterized by progressive memory loss, and there is a pressing need to identify early pathophysiological alterations that predict subsequent memory impairment. Hippocampal sharp-wave ripples (SWRs)-electrophysiological signatures of memory reactivation in the hippocampus-are a compelling candidate for this purpose. Mouse models of AD show reductions in both SWR abundance and associated slow gamma (SG) power during aging, but these alterations have yet to be directly linked to memory impairments. In aged apolipoprotein E4 knockin (apoE4-KI) mice-a model of the major genetic risk factor for AD-we find that reduced SWR abundance and associated CA3 SG power predicted spatial memory impairments measured 1-2 months later. Importantly, SWR-associated CA3 SG power reduction in young apoE4-KI mice also predicted spatial memory deficits measured 10 months later. These results establish features of SWRs as potential functional biomarkers of memory impairment in AD.

Published
2019

3. Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1

Author

Emily A. Aery Jones, Antara Rao, Misha Zilberter, Biljana Djukic, Jason S. Bant, Anna K. Gillespie, Nicole Koutsodendris, Maxine Nelson, Seo Yeon Yoon, Ky Huang, Heidi Yuan, Theodore M. Gill, Yadong Huang, and Loren M. Frank

Subjects
Male, hippocampus, Medical Physiology, Action Potentials, CA3, somatostatin, Inbred C57BL, Article, CA1, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Interneurons, parvalbumin, Entorhinal Cortex, Animals, Hippocampal, dentate gyrus, GABAergic Neurons, CA1 Region, Hippocampal, 030304 developmental biology, 0303 health sciences, musculoskeletal, neural, and ocular physiology, slow gamma, fungi, Neurosciences, CA1 Region, CA3 Region, CA3 Region, Hippocampal, sharp-wave ripple, Mice, Inbred C57BL, GABAergic interneuron, nervous system, theta, Dentate Gyrus, fast gamma, Female, Biochemistry and Cell Biology, Somatostatin, 030217 neurology & neurosurgery
Abstract

Specific classes of GABAergic neurons play specific roles in regulating information processing in the brain. In the hippocampus, two major classes – parvalbumin-expressing (PV(+)) and somatostatin-expressing (SST(+)) – differentially regulate endogenous firing patterns and target subcellular compartments of principal cells. How these classes regulate the flow of information throughout the hippocampus is poorly understood. We hypothesize that PV(+) and SST(+) interneurons in the dentate gyrus (DG) and CA3 differentially modulate CA3 patterns of output, thereby altering the influence of CA3 on CA1. We find that while suppressing either interneuron class increases DG and CA3 output, the effects on CA1 were very different. Suppressing PV(+) interneurons increases local field potential signatures of coupling from CA3 to CA1 and decreases signatures of coupling from entorhinal cortex to CA1; suppressing SST(+) interneurons has the opposite effect. Thus, DG and CA3 PV(+) and SST(+) interneurons bidirectionally modulate the flow of information through the hippocampal circuit.

Published
2021
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