1. Microbiota-dependent and -independent postnatal development of salivary immunity.
- Author
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Zubeidat K, Jaber Y, Saba Y, Barel O, Naamneh R, Netanely Y, Horev Y, Eli-Berchoer L, Shhadeh A, Yosef O, Arbib E, Betser-Cohen G, Nadler C, Shapiro H, Elinav E, Aframian DJ, Wilensky A, and Hovav AH
- Subjects
- Mice, Animals, Saliva, Salivary Glands, Immunoglobulin G, Receptors, Polymeric Immunoglobulin, Microbiota
- Abstract
While saliva regulates the interplay between the microbiota and the oral immune system, the mechanisms establishing postnatal salivary immunity are ill-defined. Here, we show that high levels of neutrophils and neonatal Fc receptor (FcRn)-transferred maternal IgG are temporarily present in the neonatal murine salivary glands in a microbiota-independent manner. During weaning, neutrophils, FcRn, and IgG decrease in the salivary glands, while the polymeric immunoglobulin receptor (pIgR) is upregulated in a growth arrest-specific 6 (GAS6)-dependent manner independent of the microbiota. Production of salivary IgA begins following weaning and relies on CD4-help, IL-17, and the microbiota. The weaning phase is characterized by a transient accumulation of dendritic cells capable of migrating from the oral mucosa to the salivary glands upon exposure to microbial challenges and activating T cells. This study reveals the postnatal mechanisms developed in the salivary glands to induce immunity and proposes the salivary glands as an immune inductive site., Competing Interests: Declaration of interests The authors declare no financial competing interests., (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
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