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1. ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury

Author

Aaron I. Weiner, Gan Zhao, Hanna M. Zayas, Nicolas P. Holcomb, Stephanie Adams-Tzivelekidis, Joanna Wong, Maria E. Gentile, Dyuthi Reddy, Joey Wei, Gargi Palashikar, Kwaku K. Quansah, and Andrew E. Vaughan

Subjects
Alveolar Epithelial Cells, Influenza, Human, Humans, Cell Differentiation, Epithelial Cells, Lung Injury, Lung, General Biochemistry, Genetics and Molecular Biology
Abstract

The lung exhibits a robust, multifaceted regenerative response to severe injuries such as influenza infection, during which quiescent lung-resident epithelial progenitors participate in two distinct reparative pathways: functionally beneficial regeneration via alveolar type 2 (AT2) cell proliferation and differentiation, and dysplastic tissue remodeling via intrapulmonary airway-resident basal p63

Published
2022

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