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Start Over Author "Pospisilik, J. Andrew" Journal cell metabolism
5 results on '"Pospisilik, J. Andrew"'

1. Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

Author

Roy, Dominic G., Chen, Jocelyn, Mamane, Victoria, Ma, Eric H., Muhire, Brejnev M., Sheldon, Ryan D., Shorstova, Tatiana, Koning, Rutger, Johnson, Radia M., Esaulova, Ekaterina, Williams, Kelsey S., Hayes, Sebastian, Steadman, Mya, Samborska, Bozena, Swain, Amanda, Daigneault, Audrey, Chubukov, Victor, Roddy, Thomas P., Foulkes, William, Pospisilik, J. Andrew, Bourgeois-Daigneault, Marie-Claude, Artyomov, Maxim N., Witcher, Michael, Krawczyk, Connie M., Larochelle, Catherine, and Jones, Russell G.

Published
2020
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2. The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes

Author

Lu, Tess Tsai-Hsiu, Heyne, Steffen, Dror, Erez, Casas, Eduard, Leonhardt, Laura, Boenke, Thorina, Yang, Chih-Hsiang, Sagar, Arrigoni, Laura, Dalgaard, Kevin, Teperino, Raffaele, Enders, Lennart, Selvaraj, Madhan, Ruf, Marius, Raja, Sunil J., Xie, Huafeng, Boenisch, Ulrike, Orkin, Stuart H., Lynn, Francis C., Hoffman, Brad G., Grün, Dominic, Vavouri, Tanya, Lempradl, Adelheid M., and Pospisilik, J. Andrew

Published
2018
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3. Human but Not Mouse Adipogenesis Is Critically Dependent on LMO3

Author

Lindroos, Josefine, Husa, Julia, Mitterer, Gerfried, Haschemi, Arvand, Rauscher, Sabine, Haas, Robert, Gröger, Marion, Loewe, Robert, Kohrgruber, Norbert, Schrögendorfer, Klaus F., Prager, Gerhard, Beck, Harald, Pospisilik, J. Andrew, Zeyda, Maximilian, Stulnig, Thomas M., Patsch, Wolfgang, Wagner, Oswald, Esterbauer, Harald, and Bilban, Martin

Published
2013
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5. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism

Author

Haschemi, Arvand, Kosma, Paul, Gille, Lars, Evans, Charles R., Burant, Charles F., Starkl, Philipp, Knapp, Bernhard, Haas, Robert, Schmid, Johannes A., Jandl, Christoph, Amir, Shahzada, Lubec, Gert, Park, Jaehong, Esterbauer, Harald, Bilban, Martin, Brizuela, Leonardo, Pospisilik, J. Andrew, Otterbein, Leo E., and Wagner, Oswald

Subjects
Lipopolysaccharides, Male, Models, Molecular, Physiology, Down-Regulation, Article, Gene Expression Regulation, Enzymologic, Cell Line, Mice, Double-Blind Method, Animals, Humans, Amino Acid Sequence, Receptors, Immunologic, Molecular Biology, Interleukin-6, Tumor Necrosis Factor-alpha, Macrophages, Cell Polarity, Cell Biology, Endotoxemia, Protein Structure, Tertiary, Mice, Inbred C57BL, Phosphotransferases (Alcohol Group Acceptor), Glucose, Phenotype, Carbohydrate Metabolism, Energy Metabolism, Transcription Factors
Abstract

Summary Immune cells are somewhat unique in that activation responses can alter quantitative phenotypes upwards of 100,000-fold. To date little is known about the metabolic adaptations necessary to mount such dramatic phenotypic shifts. Screening for novel regulators of macrophage activation, we found nonprotein kinases of glucose metabolism among the most enriched classes of candidate immune modulators. We find that one of these, the carbohydrate kinase-like protein CARKL, is rapidly downregulated in vitro and in vivo upon LPS stimulation in both mice and humans. Interestingly, CARKL catalyzes an orphan reaction in the pentose phosphate pathway, refocusing cellular metabolism to a high-redox state upon physiological or artificial downregulation. We find that CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization and uncover a rate-limiting requirement for appropriate glucose flux in macrophage polarization., Graphical Abstract Highlights ► Screened 199 human kinases for their immunoregulatory potential ► CARKL bridges glycolysis, the pentose phosphate pathway, and immune function ► CARKL focuses cellular metabolism toward a “high-redox” state ► CARKL regulation is required for macrophage polarization

Published
2011

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