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Your search keyword '"Cai, Jingjing"' showing total 7 results
Start Over Author "Cai, Jingjing" Journal cell metabolism
7 results on '"Cai, Jingjing"'

1. The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19

Author

Cai, Jingjing, Li, Haomiao, Zhang, Changjiang, Chen, Ze, Liu, Hui, Lei, Fang, Qin, Juan-Juan, Liu, Ye-Mao, Zhou, Feng, Song, Xiaohui, Zhou, Jianghua, Zhao, Yan-Ci, Wu, Bin, He, Meiling, Yang, Huilin, Zhu, Lihua, Zhang, Peng, Ji, Yan-Xiao, Zhao, Guang-Nian, Lu, Zhigang, Liu, Liming, Mao, Weiming, Liao, Xiaofeng, Lu, Haofeng, Wang, Daihong, Xia, Xigang, Huang, Xiaodong, Wei, Xiang, Xia, Jiahong, Zhang, Bing-Hong, Yuan, Yufeng, She, Zhi-Gang, Xu, Qingbo, Ma, Xinliang, Wang, Yibin, Yang, Juan, Zhang, Xin, Zhang, Xiao-Jing, and Li, Hongliang

Subjects
Patient Safety, Diabetes, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Metabolic and endocrine, Good Health and Well Being, Adrenal Cortex Hormones, Area Under Curve, COVID-19, Diabetes Mellitus, Type 2, Humans, Hyperglycemia, Length of Stay, Lymphocytes, Neutrophils, Proportional Hazards Models, ROC Curve, Risk Factors, SARS-CoV-2, Severity of Illness Index, Survival Rate, Treatment Outcome, COVID-19 Drug Treatment, corticosteroids, inflammatory status, mortality, neutrophil-to-lymphocyte ratio, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism
Abstract

Corticosteroid therapy is now recommended as a treatment in patients with severe COVID-19. But one key question is how to objectively identify severely ill patients who may benefit from such therapy. Here, we assigned 12,862 COVID-19 cases from 21 hospitals in Hubei Province equally to a training and a validation cohort. We found that a neutrophil-to-lymphocyte ratio (NLR) > 6.11 at admission discriminated a higher risk for mortality. Importantly, however, corticosteroid treatment in such individuals was associated with a lower risk of 60-day all-cause mortality. Conversely, in individuals with an NLR ≤ 6.11 or with type 2 diabetes, corticosteroid treatment was not associated with reduced mortality, but rather increased risks of hyperglycemia and infections. These results show that in the studied cohort corticosteroid treatment is associated with beneficial outcomes in a subset of COVID-19 patients who are non-diabetic and with severe symptoms as defined by NLR.

Published
2021

2. Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes

Author

Cheng, Xu, Liu, Ye-Mao, Li, Haomiao, Zhang, Xin, Lei, Fang, Qin, Juan-Juan, Chen, Ze, Deng, Ke-Qiong, Lin, Lijin, Chen, Ming-Ming, Song, Xiaohui, Xia, Meng, Huang, Xuewei, Liu, Weifang, Cai, Jingjing, Zhang, Xiao-Jing, Zhou, Feng, Zhang, Peng, Wang, Yibin, Ma, Xinliang, Xu, Qingbo, Yang, Juan, Ye, Ping, Mao, Weiming, Huang, Xiaodong, Xia, Jiahong, Zhang, Bing-Hong, Guo, Jiao, Zhu, Lihua, Lu, Zhibing, Yuan, Yufeng, Wei, Xiang, She, Zhi-Gang, Ji, Yan-Xiao, and Li, Hongliang

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Diabetes, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Metabolic and endocrine, Good Health and Well Being, Acidosis, Acidosis, Lactic, Aged, COVID-19, China, Coronavirus Infections, Diabetes Mellitus, Type 2, Female, Hospitalization, Humans, Kidney, Male, Metformin, Middle Aged, Pandemics, Pneumonia, Viral, Retrospective Studies, acidosis, coronavirus disease 2019, inflammation, metformin, mortality, treatment, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism, Biochemistry and cell biology, Medical biochemistry and metabolomics
Abstract

The safety and efficacy of anti-diabetic drugs are critical for maximizing the beneficial impacts of well-controlled blood glucose on the prognosis of individuals with COVID-19 and pre-existing type 2 diabetes (T2D). Metformin is the most commonly prescribed first-line medication for T2D, but its impact on the outcomes of individuals with COVID-19 and T2D remains to be clarified. Our current retrospective study in a cohort of 1,213 hospitalized individuals with COVID-19 and pre-existing T2D indicated that metformin use was significantly associated with a higher incidence of acidosis, particularly in cases with severe COVID-19, but not with 28-day COVID-19-related mortality. Furthermore, metformin use was significantly associated with reduced heart failure and inflammation. Our findings provide clinical evidence in support of continuing metformin treatment in individuals with COVID-19 and pre-existing T2D, but acidosis and kidney function should be carefully monitored in individuals with severe COVID-19.

Published
2020

3. In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19

Author

Zhang, Xiao-Jing, Qin, Juan-Juan, Cheng, Xu, Shen, Lijun, Zhao, Yan-Ci, Yuan, Yufeng, Lei, Fang, Chen, Ming-Ming, Yang, Huilin, Bai, Liangjie, Song, Xiaohui, Lin, Lijin, Xia, Meng, Zhou, Feng, Zhou, Jianghua, She, Zhi-Gang, Zhu, Lihua, Ma, Xinliang, Xu, Qingbo, Ye, Ping, Chen, Guohua, Liu, Liming, Mao, Weiming, Yan, Youqin, Xiao, Bing, Lu, Zhigang, Peng, Gang, Liu, Mingyu, Yang, Jun, Yang, Luyu, Zhang, Changjiang, Lu, Haofeng, Xia, Xigang, Wang, Daihong, Liao, Xiaofeng, Wei, Xiang, Zhang, Bing-Hong, Zhang, Xin, Yang, Juan, Zhao, Guang-Nian, Zhang, Peng, Liu, Peter P, Loomba, Rohit, Ji, Yan-Xiao, Xia, Jiahong, Wang, Yibin, Cai, Jingjing, Guo, Jiao, and Li, Hongliang

Subjects
Patient Safety, Prevention, Infectious Diseases, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Aged, Angiotensin-Converting Enzyme 2, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Betacoronavirus, COVID-19, Comorbidity, Coronavirus Infections, Cytokine Release Syndrome, Drug Repositioning, Drug Therapy, Combination, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypertension, Male, Middle Aged, Pandemics, Peptidyl-Dipeptidase A, Pneumonia, Viral, Retrospective Studies, SARS-CoV-2, ACEi/ARB, SARS-COV-2, mortality, statin, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism
Abstract

Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing ACE2 expression. Here, we performed a retrospective study on 13,981 patients with COVID-19 in Hubei Province, China, among which 1,219 received statins. Based on a mixed-effect Cox model after propensity score-matching, we found that the risk for 28-day all-cause mortality was 5.2% and 9.4% in the matched statin and non-statin groups, respectively, with an adjusted hazard ratio of 0.58. The statin use-associated lower risk of mortality was also observed in the Cox time-varying model and marginal structural model analysis. These results give support for the completion of ongoing prospective studies and randomized controlled trials involving statin treatment for COVID-19, which are needed to further validate the utility of this class of drugs to combat the mortality of this pandemic.

Published
2020

4. Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species

Author

Zhang, Xiao-Jing, Liu, Xiaolan, Hu, Manli, Zhao, Guo-Jun, Sun, Dating, Cheng, Xu, Xiang, Hui, Huang, Yong-Ping, Tian, Rui-Feng, Shen, Li-Jun, Ma, Jun-Peng, Wang, Hai-Ping, Tian, Song, Gan, Shanyu, Xu, Haibo, Liao, Rufang, Zou, Toujun, Ji, Yan-Xiao, Zhang, Peng, Cai, Jingjing, Wang, Zhao V., Meng, Guannan, Xu, Qingbo, Wang, Yibin, Ma, Xin-Liang, Liu, Peter P., Huang, Zan, Zhu, Lihua, She, Zhi-Gang, Zhang, Xin, Bai, Lan, Yang, Hailong, Lu, Zhibing, and Li, Hongliang

Published
2021
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5. Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

Author

Zhu, Lihua, She, Zhi-Gang, Cheng, Xu, Qin, Juan-Juan, Zhang, Xiao-Jing, Cai, Jingjing, Lei, Fang, Wang, Haitao, Xie, Jing, Wang, Wenxin, Li, Haomiao, Zhang, Peng, Song, Xiaohui, Chen, Xi, Xiang, Mei, Zhang, Chaozheng, Bai, Liangjie, Xiang, Da, Chen, Ming-Ming, Liu, Yanqiong, Yan, Youqin, Liu, Mingyu, Mao, Weiming, Zou, Jinjing, Liu, Liming, Chen, Guohua, Luo, Pengcheng, Xiao, Bing, Zhang, Changjiang, Zhang, Zixiong, Lu, Zhigang, Wang, Junhai, Lu, Haofeng, Xia, Xigang, Wang, Daihong, Liao, Xiaofeng, Peng, Gang, Ye, Ping, Yang, Jun, Yuan, Yufeng, Huang, Xiaodong, Guo, Jiao, Zhang, Bing-Hong, and Li, Hongliang

Published
2020
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7. Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease

Author

Wang, Wenxin, Hu, Manli, Liu, Hui, Zhang, Xingyuan, Li, Haomiao, Zhou, Feng, Liu, Ye-Mao, Lei, Fang, Qin, Juan-Juan, Zhao, Yan-Ci, Chen, Ze, Liu, Weifang, Song, Xiaohui, Huang, Xuewei, Zhu, Lihua, Ji, Yan-Xiao, Zhang, Peng, Zhang, Xiao-Jing, She, Zhi-Gang, Yang, Juan, Yang, Hailong, Cai, Jingjing, and Li, Hongliang

Published
2021
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