1. Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity.
- Author
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Larki, Pegah, Gharib, Ehsan, Taleghani, Mohammad Yaghoob, Khorshidi, Fatemeh, Nazemalhosseini-Mojarad, Ehsan, and Aghdaei, Hamid Asadzadeh
- Subjects
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COLON cancer , *EPIDERMAL growth factor receptors , *DISEASE progression , *ADENOCARCINOMA , *CLINICAL trials - Abstract
The detection of KRAS and BRAF mutations is a crucial step for the correct therapeutic approach and predicting the epidermal growth factor receptor (EGFR)-targeted therapy resistance of colorectal carcinomas. The concomitant KRAS and BRAF mutations occur rarely in the colorectal cancers (CRCs) with the prevalence of less than 0.001% of the cases. In patients with KRAS-mutant tumors, BRAF mutations should not regularly be tested unless the patient is participating in a clinical trial enriching for the presence of KRAS or BRAF-mutated tumor. The current report demonstrates a case with advanced adenocarcinoma of the colon showing the coexistence of KRAS and BRAF mutations and may have profound clinical implications for disease progression and therapeutic responses. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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