1. Alternative Entry Receptors for Herpes Simplex Virus and Their Roles in Disease
- Author
-
Erick Lin, Anna Zago, Miri Yoon, Klaus Pfeffer, Nanette Susmarski, Carl F. Ware, Patricia G. Spear, Yoshimi Takai, Jun Miyoshi, and Joann M. Taylor
- Subjects
Nervous system ,Simplexvirus ,Herpesvirus entry mediator ,Cancer Research ,food.ingredient ,MICROBIO ,Herpesvirus 2, Human ,Nectins ,HUMDISEASE ,Biology ,medicine.disease_cause ,Microbiology ,Article ,Lesion ,Mice ,03 medical and health sciences ,food ,Virology ,Immunology and Microbiology(all) ,medicine ,Animals ,Humans ,Receptor ,Molecular Biology ,030304 developmental biology ,Mice, Knockout ,0303 health sciences ,030306 microbiology ,Herpes Simplex ,3. Good health ,Disease Models, Animal ,medicine.anatomical_structure ,Herpes simplex virus ,Vagina ,Immunology ,Receptors, Virus ,Female ,Parasitology ,Tumor necrosis factor alpha ,Human Virus ,medicine.symptom ,Cell Adhesion Molecules ,Receptors, Tumor Necrosis Factor, Member 14 - Abstract
SummaryEither herpesvirus entry mediator (HVEM, TNFRSF14) or nectin-1 (PVRL1) is sufficient for herpes simplex virus (HSV) infection of cultured cells. The contribution of individual receptors to infection in vivo and to disease is less clear. To assess this, Tnfrsf14−/− and/or Pvrl1−/− mice were challenged intravaginally with HSV-2. Infection of the vaginal epithelium occurred in the absence of either HVEM or nectin-1 but was virtually undetectable when both receptors were absent, indicating that either HVEM or nectin-1 was necessary. Absence of nectin-1 (but not HVEM) reduced efficiency of infection of the vaginal epithelium and viral spread to the nervous system, attenuating neurological disease and preventing external lesion development. While nectin-1 proved not to be essential for infection of the nervous system, it is required for the full manifestations of disease. This study illustrates the value of mutant mice for understanding receptor contributions to disease caused by a human virus.
- Published
- 2007
- Full Text
- View/download PDF