44 results on '"Lane, David"'
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2. Isg15 controls p53 stability and functions
3. On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein
4. On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: A Brownian dynamics study
5. Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9
6. Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding
7. The p53 isoforms are differentially modified by Mdm2
8. Stress, specificity and the NEDD8 proteome
9. Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish
10. NPMc+ AML cell line shows differential protein expression and lower sensitivity to DNA-damaging and p53-inducing anticancer compounds
11. MDM4 downregulates p53 transcriptional activity and response to stress during differentiation
12. Chemical states of the N-terminal “lid” of MDM2 regulate p53 binding: Simulations reveal complexities of modulation
13. Stapled peptides in the p53 pathway: Computer simulations reveal novel interactions of the staples with the target protein
14. Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site
15. Development of a novel multiplex in vitro binding assay to profile p53-DNA interactions
16. Detection of the 113p53 protein isoform: A p53-induced protein that feeds back on the p53 pathway to modulate the p53 response in zebrafish
17. Differential binding of p53 and nutlin to MDM2 and MDMX: Computational studies
18. The Mdm2 and p53 genes are conserved in the Arachnids
19. Mdm2 and p53 are highly conserved from placozoans to man
20. Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL
21. Design of a novel MDM2 binding peptide based on the p53 family
22. Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy
23. Ubiquitination of HEXIM1 by HDM2
24. Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site
25. Dimerization of the core domain of the p53 family: A computational study
26. Hexamethylene Bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF-κB activity: Implications for cancer therapy
27. Characterization, chemical optimization and anti-tumor activity of a tubulin poison identified by a p53-based phenotypic screen
28. Targeting a nucleolar SUMO protease for degradation: A mechanism by which ARF induces SUMO conjugation
29. The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides
30. Regulation of the p14ARF promoter by DNA methylation
31. Modulation of the p53-MDM2 Interaction by Phosphorylation of Thr18: A Computational Study
32. Substrate Specificity of Cyclins Determined by Electrostatics
33. Nutlin-3 inhibits the NFκB Pathway in a p53 Dependent Manner: Implications in Lung Cancer Therapy
34. HEXIM1 and the Control of Transcription Elongation: From Cancer and Inflammation to AIDS and Cardiac Hypertrophy
35. Isg15 controls p53 stability and functions.
36. NPMc+ AML cell line shows differential protein expression and lower sensitivity to DNA-damaging and p53-inducing anticancer compounds.
37. MDM4 downregulates p53 transcriptional activity and response to stress during differentiation.
38. Detection of the 113p53 protein isoform.
39. Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL.
40. Design of a novel MDM2 binding peptide based on the p53 family.
41. Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NFκB activity.
42. Modulation of the p53-MDM2 Interaction by Phosphorylation of Thr18.
43. Substrate Specificity of Cyclins Determined by Electrostatics.
44. Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL.
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