1. PI(4,5)P2 and L-type Ca(2+) Channels Partner Up to Fine-Tune Ca(2+) Dynamics in β Cells
- Author
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Byung-Chang Suh, Jun-Hee Yeon, and Cheon-Gyu Park
- Subjects
0301 basic medicine ,Clinical Biochemistry ,Cell ,Chemical biology ,Biology ,Phosphatidylinositols ,01 natural sciences ,Biochemistry ,Cell membrane ,03 medical and health sciences ,Insulin-Secreting Cells ,Drug Discovery ,Insulin Secretion ,Pi ,medicine ,Molecular Biology ,Pharmacology ,010405 organic chemistry ,Cell Membrane ,0104 chemical sciences ,Cell biology ,030104 developmental biology ,medicine.anatomical_structure ,Membrane ,Cytoplasm ,Molecular Medicine ,Signal transduction ,Intracellular ,Signal Transduction - Abstract
The PI(4,5)P2 level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P2 and reveal how acute PI(4,5)P2 changes can alter intracellular Ca(2+) dynamics and insulin secretion in pancreatic β cells.
- Published
- 2016