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Start Over Author "Cao YA" Journal cell biology international
12 results on '"Cao YA"'

12. NF-kappaB inhibitors induce lytic cytotoxicity in Epstein-Barr virus-positive nasopharyngeal carcinoma cells.

Author

Liu SF, Wang H, Lin XC, Xiang H, Deng XY, Li W, Tang M, and Cao Y

Subjects
Antiviral Agents pharmacology, Cell Line, Tumor, Cell Nucleus metabolism, Cytoplasm metabolism, Epstein-Barr Virus Infections metabolism, Ganciclovir pharmacology, Herpesvirus 4, Human physiology, Humans, NF-kappa B metabolism, Nasopharyngeal Neoplasms metabolism, Nasopharyngeal Neoplasms virology, Transcription Factor RelA metabolism, Virus Activation, Epstein-Barr Virus Infections virology, Herpesvirus 4, Human drug effects, NF-kappa B antagonists & inhibitors, Nasopharyngeal Neoplasms pathology, Nitriles pharmacology, Oligopeptides pharmacology, Sulfones pharmacology
Abstract

Epstein-Barr virus (EBV) infection in tumor cells is generally restricted to the latent forms of viral infection. Switching the latent form of viral infection into the lytic form may induce tumor cell death. An important nuclear factor, nuclear factor (NF)-kappaB, is thought to play an essential role in EBV lytic infection; high levels of NF-kappaB can inhibit EBV lytic replication. In this study, we tested the effect of inducing EBV lytic replication using two NF-kappaB inhibitors: Bay11-7082 and Z-LLF-CHO, to reveal the possibility of targeting EBV-positive cancer therapy with these two NF-kappaB inhibitors. Our results showed that Bay11-7082 and Z-LLF-CHO reactivated EBV in a dose-dependent manner, thus resulting in EBV-positive 5-8F cell death. In contrast, there was no significant effect on EBV-negative HNE3 cells. When ganciclovir was used in combination with either Bay11-7082 or Z-LLF-CHO to treat 5-8F cells, the cytotoxic effect of the NF-kappaB inhibitor was amplified. The finding indicates that inhibiting the NF-kappaB activity of EBV-positive cells can induce lytic replication of EBV and cause lytic cytotoxicity against these cells.

Published
2008
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