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Your search keyword '"Ofer Regev"' showing total 2 results
Start Over Author "Ofer Regev" Journal cell adhesion & migration
2 results on '"Ofer Regev"'

1. Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells

Author

Francesco Roncato, Ofer Regev, Sandeep Kumar Yadav, and Ronen Alon

Subjects
cytoskeleton, motility, cancer, metastasis, taxol, Cytology, QH573-671
Abstract

Microtubules (MTs) control cell shape and intracellular cargo transport. The role of MT turnover in the migration of slow-moving cells through endothelial barriers remains unclear. To irreversibly interfere with MT disassembly, we have used the MT-stabilizing agent zampanolide (ZMP) in Β16F10 melanoma as amodel of slow-moving cells. ZMP-treated B16 cells failed to follow chemotactic gradients across rigid confinements and could not generate stable sub-endothelial pseudopodia under endothelial monolayers. In vivo, ZMP-treated Β16 cells failed to extravasate though lung capillaries. In contrast to melanoma cells, the chemotaxis and transendothelial migration of ZMP-treated Tcells were largely conserved. This is afirst demonstration that MT disassembly is akey checkpoint in the directional migration of cancer cells but not of lymphocytes.

Published
2021
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2. Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells

Author

Ronen Alon, Ofer Regev, Francesco Roncato, and Sandeep Kumar Yadav

Subjects
Male, 0301 basic medicine, Short Communication, T-Lymphocytes, Motility, macromolecular substances, Microtubules, Metastasis, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Cell Movement, Microtubule, Cell Line, Tumor, medicine, cancer, metastasis, Animals, Pseudopodia, Cytoskeleton, Melanoma, taxol, QH573-671, Chemistry, Brief Report, Chemotaxis, Transendothelial and Transepithelial Migration, Cancer, Cell Biology, medicine.disease, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, motility, 030220 oncology & carcinogenesis, Macrolides, Cytology, Intracellular
Abstract

Microtubules (MTs) control cell shape and intracellular cargo transport. The role of MT turnover in the migration of slow-moving cells through endothelial barriers remains unclear. To irreversibly interfere with MT disassembly, we have used the MT-stabilizing agent zampanolide (ZMP) in Β16F10 melanoma as amodel of slow-moving cells. ZMP-treated B16 cells failed to follow chemotactic gradients across rigid confinements and could not generate stable sub-endothelial pseudopodia under endothelial monolayers. In vivo, ZMP-treated Β16 cells failed to extravasate though lung capillaries. In contrast to melanoma cells, the chemotaxis and transendothelial migration of ZMP-treated Tcells were largely conserved. This is afirst demonstration that MT disassembly is akey checkpoint in the directional migration of cancer cells but not of lymphocytes.

Published
2021

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