To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2006.05.027 Byline: Elizabeth J. Tran (1), Susan R. Wente (1) Abstract: The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. Altering the interactions between transport receptors and their cargo has been shown to be a major regulatory mechanism to control traffic through NPCs. New evidence now suggests that NPC proteins play active roles in translocation, and that transport is also controlled by dynamic changes in NPC composition and architecture. This view of ever-changing NPCs necessitates the re-evaluation of current models of nuclear transport and how this process is regulated. Author Affiliation: (1) Department of Cell and Developmental Biology, Vanderbilt University Medical Center, U-3209 MRBIII, 465 21.sup.st Avenue South, Nashville, TN 37232 USA