1. Tumor induction of VEGF promoter activity in stromal cells
- Author
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Fukumura, Dai, Xavier, Ramnik, Sugiura, Takeyuki, Chen, Yi, Park, Eun-Chung, Lu, Naifang, Selig, Martin, Nielsen, Gunnlaugur, Taksir, Tatyana, Jain, Rakesh K., and Seed, Brian
- Subjects
Biological sciences - Abstract
Vascular endothelial growth factor (VEGF) promoter activation associated with normal wound repair is manifested in transgenic mice that express an engineered version of the A. victoria green fluorescent protein under the control of the human VEGF promoter by fluorescence developing at the wound margins. This fluorescence extends throughout the granulation tissue. VEGF is widely expressed in normal tissues, and it seems likely in principle that almost any cell type could act as a source for VEGF upon hypoxic or ischemic demand.
- Published
- 1998