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1. Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpefat mice

Author

Cool, David R., Normant, Emmanuel, Shen, Fu-sheng, Chen, Hao-Chia, Pannell, Lewis, Zhang, Ying, and Loh, Y. Peng

Subjects
Proteases -- Research, Endocrinology -- Research, Suppression, Genetic -- Research, Biological sciences
Abstract

A mechanism for sorting secretory proteins into granules for release through the regulated secretory pathway in endocrine-neuroendocrine cells is suggested. The approach involves binding the proteins to a sorting receptor at the trans-Golgi network, proceeded by budding and granule formation. Membrane-associated carboxypeptidase E in pituitary Golgi-enriched and secretory granule membranes is the sorting receptor.

Published
1997

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