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15 results on '"Ming, Guo-li"'

2. A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

Author

Jacob, Fadi, primary, Salinas, Ryan D., additional, Zhang, Daniel Y., additional, Nguyen, Phuong T.T., additional, Schnoll, Jordan G., additional, Wong, Samuel Zheng Hao, additional, Thokala, Radhika, additional, Sheikh, Saad, additional, Saxena, Deeksha, additional, Prokop, Stefan, additional, Liu, Di-ao, additional, Qian, Xuyu, additional, Petrov, Dmitriy, additional, Lucas, Timothy, additional, Chen, H. Isaac, additional, Dorsey, Jay F., additional, Christian, Kimberly M., additional, Binder, Zev A., additional, Nasrallah, MacLean, additional, Brem, Steven, additional, O’Rourke, Donald M., additional, Ming, Guo-li, additional, and Song, Hongjun, additional

Published
2020
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3. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates

Author

Tamagnone, Luca, Artigiani, Stefania, Chen, Hang, He, Zhigang, Ming, Guo-li, Song, Hong-jun, Chedotal, Alain, Winberg, Margaret L., Goodman, Corey S., Poo, Mu-ming, Tessier-Lavigne, Marc, and Comoglio, Paolo M.

Subjects
Cytochemistry -- Research, Cellular signal transduction -- Research, Cell interaction -- Research, Neurons -- Physiological aspects, Vertebrates -- Genetic aspects, Biological sciences
Abstract

Plexins, a large family of vertebrate receptors for secreted, transmembrane, and GPI-anchored semaphorins, are discussed. The human plexin gene family has been shown to have four subfamilies with a minimum of nine members. The plexins trigger a novel signal transduction pathway that controls cell repulsion.

Published
1999

4. DISC1 Partners with GSK3[beta] in Neurogenesis

Author

Ming, Guo-Li and Song, Hongjun

Subjects
Mental illness -- Development and progression, Neurosciences, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2009.03.005 Byline: Guo-li Ming (1)(2)(3), Hongjun Song (1)(2)(3) Abstract: The protein DISC1, encoded by a gene implicated in schizophrenia susceptibility, regulates the development of postmitotic neurons. now report that DISC1 also regulates the proliferation of embryonic and adult neural progenitor cells through the GSK3[beta]/[beta]-catenin pathway, providing new insights into how susceptibility genes may contribute to the etiology of psychiatric disorders. Author Affiliation: (1) Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA (2) Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA (3) The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Published
2009

5. A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

Author

Berg, Daniel A., primary, Su, Yijing, additional, Jimenez-Cyrus, Dennisse, additional, Patel, Aneek, additional, Huang, Nancy, additional, Morizet, David, additional, Lee, Stephanie, additional, Shah, Reeti, additional, Ringeling, Francisca Rojas, additional, Jain, Rajan, additional, Epstein, Jonathan A., additional, Wu, Qing-Feng, additional, Canzar, Stefan, additional, Ming, Guo-Li, additional, Song, Hongjun, additional, and Bond, Allison M., additional

Published
2019
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7. Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation

Author

Yoon, Ki-Jun, primary, Ringeling, Francisca Rojas, additional, Vissers, Caroline, additional, Jacob, Fadi, additional, Pokrass, Michael, additional, Jimenez-Cyrus, Dennisse, additional, Su, Yijing, additional, Kim, Nam-Shik, additional, Zhu, Yunhua, additional, Zheng, Lily, additional, Kim, Sunghan, additional, Wang, Xinyuan, additional, Doré, Louis C., additional, Jin, Peng, additional, Regot, Sergi, additional, Zhuang, Xiaoxi, additional, Canzar, Stefan, additional, He, Chuan, additional, Ming, Guo-li, additional, and Song, Hongjun, additional

Published
2017
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8. Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Author

Qian, Xuyu, primary, Nguyen, Ha Nam, additional, Song, Mingxi M., additional, Hadiono, Christopher, additional, Ogden, Sarah C., additional, Hammack, Christy, additional, Yao, Bing, additional, Hamersky, Gregory R., additional, Jacob, Fadi, additional, Zhong, Chun, additional, Yoon, Ki-jun, additional, Jeang, William, additional, Lin, Li, additional, Li, Yujing, additional, Thakor, Jai, additional, Berg, Daniel A., additional, Zhang, Ce, additional, Kang, Eunchai, additional, Chickering, Michael, additional, Nauen, David, additional, Ho, Cheng-Ying, additional, Wen, Zhexing, additional, Christian, Kimberly M., additional, Shi, Pei-Yong, additional, Maher, Brady J., additional, Wu, Hao, additional, Jin, Peng, additional, Tang, Hengli, additional, Song, Hongjun, additional, and Ming, Guo-li, additional

Published
2016
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10. Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia

Author

Kim, Ju Young, primary, Liu, Cindy Y., additional, Zhang, Fengyu, additional, Duan, Xin, additional, Wen, Zhexing, additional, Song, Juan, additional, Feighery, Emer, additional, Lu, Bai, additional, Rujescu, Dan, additional, St Clair, David, additional, Christian, Kimberly, additional, Callicott, Joseph H., additional, Weinberger, Daniel R., additional, Song, Hongjun, additional, and Ming, Guo-li, additional

Published
2012
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13. Disrupted-In-Schizophrenia 1 Regulates Integration of Newly Generated Neurons in the Adult Brain

Author

Duan, Xin, primary, Chang, Jay H., additional, Ge, Shaoyu, additional, Faulkner, Regina L., additional, Kim, Ju Young, additional, Kitabatake, Yasuji, additional, Liu, Xiao-bo, additional, Yang, Chih-Hao, additional, Jordan, J. Dedrick, additional, Ma, Dengke K., additional, Liu, Cindy Y., additional, Ganesan, Sundar, additional, Cheng, Hwai-Jong, additional, Ming, Guo-li, additional, Lu, Bai, additional, and Song, Hongjun, additional

Published
2007
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15. Temporal Control of Mammalian Cortical Neurogenesis by m 6 A Methylation.

Author

Yoon KJ, Ringeling FR, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D, Su Y, Kim NS, Zhu Y, Zheng L, Kim S, Wang X, Doré LC, Jin P, Regot S, Zhuang X, Canzar S, He C, Ming GL, and Song H

Subjects
Animals, Cell Cycle, Gene Expression Regulation, Gene Expression Regulation, Developmental, Gene Knockdown Techniques, Humans, Methylation, Methyltransferases genetics, Methyltransferases metabolism, Mice, Mice, Knockout, Neural Stem Cells metabolism, Organoids metabolism, Prosencephalon cytology, Prosencephalon metabolism, RNA Stability, Neurogenesis, Prosencephalon embryology, RNA Processing, Post-Transcriptional, RNA, Messenger metabolism
Abstract

N 6 -methyladenosine (m 6 A), installed by the Mettl3/Mettl14 methyltransferase complex, is the most prevalent internal mRNA modification. Whether m 6 A regulates mammalian brain development is unknown. Here, we show that m 6 A depletion by Mettl14 knockout in embryonic mouse brains prolongs the cell cycle of radial glia cells and extends cortical neurogenesis into postnatal stages. m 6 A depletion by Mettl3 knockdown also leads to a prolonged cell cycle and maintenance of radial glia cells. m 6 A sequencing of embryonic mouse cortex reveals enrichment of mRNAs related to transcription factors, neurogenesis, the cell cycle, and neuronal differentiation, and m 6 A tagging promotes their decay. Further analysis uncovers previously unappreciated transcriptional prepatterning in cortical neural stem cells. m 6 A signaling also regulates human cortical neurogenesis in forebrain organoids. Comparison of m 6 A-mRNA landscapes between mouse and human cortical neurogenesis reveals enrichment of human-specific m 6 A tagging of transcripts related to brain-disorder risk genes. Our study identifies an epitranscriptomic mechanism in heightened transcriptional coordination during mammalian cortical neurogenesis., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2017
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