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Your search keyword '"Michele, Daniel E."' showing total 2 results
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2 results on '"Michele, Daniel E."'

1. Disruption of Dag1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration

Author

Cohn, Ronald D., Henry, Michael D., Michele, Daniel E., Barresi, Rita, Saito, Fumiaki, Moore, Steven A., Flanagan, Jason D., Skwarchuk, Mark W., Robbins, Michael E., Mendell, Jerry W., Williamson, Roger A., and Campbell, Kevin P.

Subjects
Muscular dystrophy -- Genetic aspects, Striated muscle -- Physiological aspects, Genetic regulation -- Physiological aspects, Regeneration (Biology) -- Analysis, Biological sciences
Abstract

The pathogenesis of muscular dystrophy is manifested via perturbation of satellite cell function, which in turn disrupts the dystroglycan (DAG1) gene and dystrophin-glycoprotein complex, and insufficient repair of skeletal muscle cells leading to muscular dystrophy. However, the self-renewing potential is not decreased during aging and during repetitive cycles of muscle de- and regeneration.

Published
2002

2. Molecular recognition by LARGE is essential for expression of functional dystroglycan

Author

Kanagawa, Motoi, Oldstone, Michael B.A., Michele, Daniel E., Dumanski, Jan P., Saito, Fumiaki, Campbell, Kevin P., Kunz, Stefan, Yoshida-Moriguchi, Takako, Barresi, Rita, Muschler, John, and Kobayashi, Yvonne M.

Subjects
Laminin -- Research, Gene expression -- Research, Mucins -- Research, Biological sciences
Abstract

The importance of the N-terminal domain and a portion of the mucin-like domain of alpha-dystroglycan for high-affinity laminin-receptor function are examined. The molecular recognition of dystroglycan by LARGE is the key determinant in the biosynthetic pathway for the production of mature and functional dystroglycan.

Published
2004

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