1. Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
- Author
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Takuya Sekine, André Perez-Potti, Olga Rivera-Ballesteros, Kristoffer Strålin, Jean-Baptiste Gorin, Annika Olsson, Sian Llewellyn-Lacey, Habiba Kamal, Gordana Bogdanovic, Sandra Muschiol, David J. Wullimann, Tobias Kammann, Johanna Emgård, Tiphaine Parrot, Elin Folkesson, Olav Rooyackers, Lars I. Eriksson, Jan-Inge Henter, Anders Sönnerborg, Tobias Allander, Jan Albert, Morten Nielsen, Jonas Klingström, Sara Gredmark-Russ, Niklas K. Björkström, Johan K. Sandberg, David A. Price, Hans-Gustaf Ljunggren, Soo Aleman, Marcus Buggert, Mira Akber, Lena Berglin, Helena Bergsten, Susanna Brighenti, Demi Brownlie, Marta Butrym, Benedict Chambers, Puran Chen, Martin Cornillet Jeannin, Jonathan Grip, Angelica Cuapio Gomez, Lena Dillner, Isabel Diaz Lozano, Majda Dzidic, Malin Flodström Tullberg, Anna Färnert, Hedvig Glans, Alvaro Haroun-Izquierdo, Elizabeth Henriksson, Laura Hertwig, Sadaf Kalsum, Efthymia Kokkinou, Egle Kvedaraite, Marco Loreti, Magalini Lourda, Kimia Maleki, Karl-Johan Malmberg, Nicole Marquardt, Christopher Maucourant, Jakob Michaelsson, Jenny Mjösberg, Kirsten Moll, Jagadees Muva, Johan Mårtensson, Pontus Nauclér, Anna Norrby-Teglund, Laura Palma Medina, Björn Persson, Lena Radler, Emma Ringqvist, John Tyler Sandberg, Ebba Sohlberg, Tea Soini, Mattias Svensson, Janne Tynell, Renata Varnaite, Andreas Von Kries, and Christian Unge
- Subjects
Adult ,Male ,T-Lymphocytes ,media_common.quotation_subject ,T cell ,Pneumonia, Viral ,Antibodies, Viral ,Asymptomatic ,Article ,General Biochemistry, Genetics and Molecular Biology ,Epitope ,purl.org/becyt/ford/3.3 [https] ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Cytotoxic T cell ,skin and connective tissue diseases ,Asymptomatic Infections ,Pandemics ,030304 developmental biology ,media_common ,Sars-Cov-2 ,0303 health sciences ,biology ,SARS-CoV-2 ,Convalescence ,fungi ,COVID-19 ,Middle Aged ,Phenotype ,body regions ,medicine.anatomical_structure ,Immunology ,biology.protein ,purl.org/becyt/ford/3 [https] ,Female ,Antibody ,medicine.symptom ,Coronavirus Infections ,Immunologic Memory ,Memory T cell ,030217 neurology & neurosurgery - Abstract
Summary SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We here systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19., Highlights 1. Acute phase SARS-CoV-2-specific T cells display an activated cytotoxic phenotype 2. Broad and polyfunctional SARS-CoV-2-specific T cell responses in convalescent phase 3. Detection of SARS-CoV-2-specific T cell responses also in seronegative individuals
- Published
- 2020