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4 results on '"Kishihara, Kenji"'

1. Mice deficient for the 55kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

Author

Pfeffer, Klaus, Matsuyama, Toshifumi, Kundig, Thomas M., Wakehan, Andrew, Kishihara, Kenji, Shahinian, Arda, Wiegmann, Katja, Ohashi, Pamela S., Kronke, Martin, and Mak, Tak W.

Subjects
Tumor necrosis factor -- Research, Cell receptors -- Research, Toxicological interactions -- Research, Biological sciences
Abstract

A mutant mouse strain that is deficient in the 55 kd receptor of the tumor necrosis factor (TNFRp55) was established. The splenocytes of TNFRp55 -/- mice express normal numbers of high affinity TNFRp75, indicating that the expression of TNFp75 is independent of TNFp55. Moreover, major alterations with respect to TNF signaling and host responses to specific stimuli were demonstrated. The findings suggest that TNFRp55 mediated signals play a role in both toxic and protective effects of TNF in vivo.

Published
1993

2. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

Author

Matsuyama, Toshifumi, primary, Kimura, Tohru, additional, Kitagawa, Motoo, additional, Pfeffer, Klaus, additional, Kawakami, Takatoshi, additional, Watanabe, Nobumasa, additional, Kündig, Thomas M., additional, Amakawa, Ryuichi, additional, Kishihara, Kenji, additional, Wakeham, Andrew, additional, Potter, Julia, additional, Furlonger, Caren L., additional, Narendran, Arumugavadivel, additional, Suzuki, Haruhiko, additional, Ohashi, Pamela S., additional, Paige, Christopher J., additional, Taniguchi, Tadatsugu, additional, and Mak, Tak W., additional

Published
1993
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3. Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

Author

Kishihara, Kenji, primary, Penninger, Josef, additional, Wallace, Valerie A., additional, Kündig, Thomas M., additional, Kawal, Kazuhiro, additional, Wakeham, Andrew, additional, Timms, Emma, additional, Pfeffer, Klaus, additional, Ohashi, Pamela S., additional, Thomas, Matthew L., additional, Furlonger, Caren, additional, Paige, Christopher J., additional, and Mak, Tak W., additional

Published
1993
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