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Your search keyword '"Kayagaki, Nobuhiko"' showing total 4 results
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4 results on '"Kayagaki, Nobuhiko"'

1. Cell death

Author

Newton, Kim, Strasser, Andreas, Kayagaki, Nobuhiko, and Dixit, Vishva M.

Published
2024
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2. Selective activation of PFKL suppresses the phagocytic oxidative burst

Author

Amara, Neri, primary, Cooper, Madison P., additional, Voronkova, Maria A., additional, Webb, Bradley A., additional, Lynch, Eric M., additional, Kollman, Justin M., additional, Ma, Taylur, additional, Yu, Kebing, additional, Lai, Zijuan, additional, Sangaraju, Dewakar, additional, Kayagaki, Nobuhiko, additional, Newton, Kim, additional, Bogyo, Matthew, additional, Staben, Steven T., additional, and Dixit, Vishva M., additional

Published
2021
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3. IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Author

Varfolomeev, Eugene, primary, Blankenship, John W., additional, Wayson, Sarah M., additional, Fedorova, Anna V., additional, Kayagaki, Nobuhiko, additional, Garg, Parie, additional, Zobel, Kerry, additional, Dynek, Jasmin N., additional, Elliott, Linda O., additional, Wallweber, Heidi J.A., additional, Flygare, John A., additional, Fairbrother, Wayne J., additional, Deshayes, Kurt, additional, Dixit, Vishva M., additional, and Vucic, Domagoj, additional

Published
2007
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4. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

Author

Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, Flygare JA, Fairbrother WJ, Deshayes K, Dixit VM, and Vucic D

Subjects
Animals, Cell Line, Humans, Inhibitor of Apoptosis Proteins genetics, Mice, Molecular Structure, Neoplasms metabolism, Neoplasms pathology, Proteasome Endopeptidase Complex metabolism, Protein Structure, Tertiary, Signal Transduction physiology, Ubiquitination, Apoptosis physiology, Inhibitor of Apoptosis Proteins antagonists & inhibitors, Inhibitor of Apoptosis Proteins metabolism, NF-kappa B metabolism, Polyubiquitin metabolism, Tumor Necrosis Factor-alpha metabolism
Abstract

Inhibitor of apoptosis (IAP) proteins are antiapoptotic regulators that block cell death in response to diverse stimuli. They are expressed at elevated levels in human malignancies and are attractive targets for the development of novel cancer therapeutics. Herein, we demonstrate that small-molecule IAP antagonists bind to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs. The IAP antagonists also induce cell death that is dependent on TNF signaling and de novo protein biosynthesis. Additionally, the c-IAP proteins were found to function as regulators of NF-kappaB signaling. Through their ubiquitin E3 ligase activities c-IAP1 and c-IAP2 promote proteasomal degradation of NIK, the central ser/thr kinase in the noncanonical NF-kappaB pathway.

Published
2007
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