Search

Your search keyword '"Jack D. Bui"' showing total 3 results
Start Over Author "Jack D. Bui" Journal cell
3 results on '"Jack D. Bui"'

1. SnapShot: Cancer immunoediting

Author

Siva Karthik Varanasi, Susan M. Kaech, and Jack D. Bui

Subjects
Neoplasms, Mutation, Tumor Microenvironment, Humans, Tumor Escape, General Biochemistry, Genetics and Molecular Biology
Abstract

In the tumor microenvironment, immune cells and tumor cells interact in a process called cancer immunoediting, giving rise to changes in gene expression, metabolism, mutational burden, and cellularity in the tumor. This SnapShot compares endogenous versus therapy-induced cancer immunoediting and outlines the molecular and cellular characteristics of interactions that result in complete tumor regression versus tumor escape and progression. To view this SnapShot, open or download the PDF.

Published
2022

2. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Author

Miho Nakajima, Maša Alečković, Linda Bojmar, Avigdor Scherz, Benjamin A. Garcia, Jacqueline Bromberg, Irit Sagi, Pernille Lauritzen, Yuan Liu, Michael F. Berger, Kayleen A. Bailey, Kofi Ennu Gyan, Moshe Oren, Kei Sugiura, Charles M. Rudin, Zoe Posner, Shakeel Modak, Milica Tesic Mark, Joshua S. Jolissant, Irina Matei, Henrik Molina, Constantinos P. Zambirinis, Mark A. LaBarge, G. Praveen Raju, Srikanth R. Ambati, Jeanine Baisch, Mariel Marrano, Tanya M. Trippett, Caitlin Williams, Alexander J. Chou, Ayako Hashimoto, David J. Pisapia, Michele Cioffi, Stephanie Vitolano, Norman J. Lacayo, Yves A. DeClerck, Geraldine P. Wright, Michael A. Hollingsworth, Joe DeStefano, Vinod P. Balachandran, Michael H.A. Roehrl, Mary Petriccione, Mary S. Brady, Kim Kramer, Héctor Peinado, Guillermo García-Santos, David R. Jones, Haiying Zhang, Mina J. Bissell, Jonathan M. Hernandez, Naoko Takahashi, Yonathan Ararso, L. Miles Schaeffer, Daniela Freitas, Enrico Danzer, David P. Kelsen, Ben Z. Stanger, Paul A. Meyers, Stephen S. Roberts, Cyrus M. Ghajar, Angela Di Giannatale, Jack D. Bui, William R. Jarnagin, Virginia Pascual, Eileen M. O'Reilly, Todd E. Heaton, David Lyden, Amber L. Simpson, Michael P. La Quaglia, Arti Shukla, Serena Lucotti, Vinagolu K. Rajasekhar, Amina Ahmed, John H. Healey, Robert E. Schwartz, Candia M. Kenific, Emily K. Slotkin, Laura Nogués, Kristy A. Brown, Søren Heissel, Daniel Diolaiti, Loïc Steiner, Ruth Scherz-Shouval, Yosef Yarden, Theresa C. Vincent, Martin R. Weiser, Fatima Cardoso, Han Sang Kim, Ayuko Hoshino, Huajuan Wang, Sujit Sheth, Fanny A. Pelissier Vatter, Yibin Kang, Maria Donzelli, Laurence Blavier, Benjamin A. Krantz, Alexander E. Davies, Thomas C. Caffrey, Yusuke Ogitani, Cheryl Fischer, Maria de Sousa, Gonçalo Rodrigues, Ellen M. Basu, Weston Buehring, Surinder K. Batra, Maneesh Jain, Diane M. Simeone, Leonard H. Wexler, Alberto Benito-Martin, Yasmin Khakoo, Lee Ganshaw, Katharine Offer, Paul M. Grandgenett, Bruno Costa-Silva, Kevin C. De Braganca, Mahathi Malladi, and Ashton Harris

Subjects
Proteomics, Cancer microenvironment, Proteome, Biology, Sensitivity and Specificity, Exosome, Article, Tetraspanin 29, General Biochemistry, Genetics and Molecular Biology, Cell Line, Machine Learning, Tumour biomarkers, Plasma, Extracellular Vesicles, Mice, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Biomarkers, Tumor, medicine, Animals, Humans, Liquid biopsy, 030304 developmental biology, 0303 health sciences, Proteomic Profile, Microfilament Proteins, HSC70 Heat-Shock Proteins, Cancer, Extracellular vesicle, medicine.disease, Research Highlight, Mice, Inbred C57BL, rap GTP-Binding Proteins, Cancer research, Biomarkers, 030217 neurology & neurosurgery, Cancer of unknown primary origin
Abstract

Summary There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in 426 human samples from tissue explants (TEs), plasma, and other bodily fluids. Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. To confirm that EVPs are ideal diagnostic tools, we analyzed proteomes of TE- (n = 151) and plasma-derived (n = 120) EVPs. Comparison of TE EVPs identified proteins (e.g., VCAN, TNC, and THBS2) that distinguish tumors from normal tissues with 90% sensitivity/94% specificity. Machine-learning classification of plasma-derived EVP cargo, including immunoglobulins, revealed 95% sensitivity/90% specificity in detecting cancer. Finally, we defined a panel of tumor-type-specific EVP proteins in TEs and plasma, which can classify tumors of unknown primary origin. Thus, EVP proteins can serve as reliable biomarkers for cancer detection and determining cancer type.

Published
2020

3. A Role for CaMKII in T Cell Memory

Author

Jack D. Bui, Sébastien Calbo, Stephen M. Hedrick, Kristine Hayden-Martinez, Phyllis Gardner, and Lawrence P. Kane

Subjects
Genetically modified mouse, medicine.medical_specialty, Calmodulin, Lymphoid Tissue, T-Lymphocytes, Cellular differentiation, T cell, Mice, Transgenic, Thymus Gland, Lymphocyte Activation, General Biochemistry, Genetics and Molecular Biology, Immunophenotyping, Interferon-gamma, Mice, Ca2+/calmodulin-dependent protein kinase, Internal medicine, medicine, Animals, Humans, Cytotoxic T cell, Transgenes, IL-2 receptor, biology, Kinase, Biochemistry, Genetics and Molecular Biology(all), Cell biology, Isoenzymes, medicine.anatomical_structure, Endocrinology, Calcium-Calmodulin-Dependent Protein Kinases, biology.protein, Interleukin-4, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Immunologic Memory, Cell Division
Abstract

In order to study the role of calcium/calmodulin kinase II (CaMKII) in T cells, we generated transgenic mice expressing CaMKIIγB* (T287D), a partially calciumindependent mutant of CaMKIIγB. In these mice, the size of the thymus was increased 1.5- to 2-fold, at least in part due to an increase in the lifespan of double-positive (DP) thymocytes. More importantly, there was an increase in the number of T cells in the secondary lymphoid organs that had acquired an antigen-dependent memory phenotype. These T cells were bonafide memory cells as assessed by a variety of criteria. In addition, T cells from wild-type mice acquired calcium-independent CaMKII activity after several rounds of antigen-stimulated division. We propose that CaMKII controls a distinct process of activation-induced cellular differentiation.

Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results