1. Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes
- Author
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Annie Hampe, Francis Galibert, Charles J. Sherr, Ivan Laprevotte, and Louis A. Fedele
- Subjects
animal structures ,Polyproteins ,Genes, Viral ,viruses ,Sarcoma Viruses, Feline ,Gene Products, gag ,Biology ,Feline leukemia virus ,General Biochemistry, Genetics and Molecular Biology ,Substrate Specificity ,Viral Proteins ,Amino Acid Sequence ,Tyrosine ,Phosphotyrosine ,Gene ,chemistry.chemical_classification ,Genetics ,Rous sarcoma virus ,Base Sequence ,Kinase ,Oncogenes ,Cell Transformation, Viral ,biology.organism_classification ,Biological Evolution ,Molecular biology ,Amino acid ,Retroviridae ,Genes ,chemistry ,Protein Kinases ,Proto-oncogene tyrosine-protein kinase Src - Abstract
The nucleotide sequences encoding the transforming polyproteins of the Snyder-Theilen and Gardner-Arnstein strains of feline sarcoma virus (FeSV) have been determined. These sequences include a viral transforming gene ( v-fes ), derived from cellular proto-oncogene sequences ( c-fes ) of domestic cats by recombination with feline leukemia virus (FeLV). The v-fes sequences are predicted to encode a polypeptide domain strikingly similar to that specified by the transforming gene ( v-fps ) of the avian Fujinami sarcoma virus. In addition, the 3′ 0.8 kilobase pairs of v-fes encode amino acid sequences homologous to the carboxy-terminal portion of pp60 src , the transforming protein encoded by the avian Rous sarcoma virus src gene. Thus different feline and avian retroviral transforming genes, all of which encode functionally related proteins with associated tyrosine-specific kinase activities, must be derived from divergent members of the same protooncogene family.
- Published
- 1982
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