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1. Somatic inactivation of Pkd2 results in polycystic kidney disease.

Author

Wu, Guanqing, D'Agati, Vivette, Yiqiang Cai, Markowitz, Glen, Jong Hoon Park, Reynolds, David M., Maeda, Yoshiko, Le, Thanh C., Hou, Jr., Harry, Kucherlapati, Raju, Edelmann, Winfried, and Somlo, Stefan

Subjects
*POLYCYSTIC kidney disease
Abstract

Presents information stating that autosomal dominant polycystic kidney disease is caused by germline mutations in PKD2. Information on the analysis of the WS25 Pkd2 mutant allele; Details on kidney cysts in WS25 Pkd mutant mice; Indepth look at the loss of polycystin-2 expression which leads to cyst formation; More information on germline mutation in PKD2 which relates to kidney disease.

Published
1998
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