Search

Your search keyword '"Histones -- Structure"' showing total 2 results
Start Over Descriptor "Histones -- Structure" Journal cell
2 results on '"Histones -- Structure"'

1. New histone incorporation marks sites of UV repair in human cells

Author

Polo, Sophie E., Roche, Daniele, and Almouzni, Genevieve

Subjects
Histones -- Structure, Histones -- Research, DNA repair -- Research, DNA damage -- Research, Biological sciences
Abstract

An approach to follow new histone deposition upon ultraviolet (UV) irradiation in human cells is devised. It is shown that new H3.1 histones get incorporated in vivo at repair sites and it is concluded that chromatin restoration after damage cannot rely simply on histone recycling.

Published
2006

2. Structural basis for the histone chaperone activity of Asf1

Author

English, Christine M., Adkins, Melissa W., Carson, Joshua J., Churchill, Mair E.A., and Tyler, Jessica K.

Subjects
DNA repair -- Research, Histones -- Research, Histones -- Structure, Molecular chaperones -- Structure, Molecular chaperones -- Research, Genetic transcription -- Research, Biological sciences
Abstract

The crystal structure of anti-silencing function 1 (Asf1) bound to histones H3/H4 is determined, which reveals how a histone chaperone binds histones and how the structures of H3 and H4 differ outside of the histone octamer. The Asf1-H3/H4 structure has indicated a 'strand-capture' mechanism whereby the H4 tail acts as a lever to facilitate chromatin disassembly/assembly that might be used by histone chaperones.

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results