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11 results on '"Doranz, Benjamin J."'

1. Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress

Author

Williamson, Lauren E., primary, Reeder, Kristen M., additional, Bailey, Kevin, additional, Tran, Minh H., additional, Roy, Vicky, additional, Fouch, Mallorie E., additional, Kose, Nurgun, additional, Trivette, Andrew, additional, Nargi, Rachel S., additional, Winkler, Emma S., additional, Kim, Arthur S., additional, Gainza, Christopher, additional, Rodriguez, Jessica, additional, Armstrong, Erica, additional, Sutton, Rachel E., additional, Reidy, Joseph, additional, Carnahan, Robert H., additional, McDonald, W. Hayes, additional, Schoeder, Clara T., additional, Klimstra, William B., additional, Davidson, Edgar, additional, Doranz, Benjamin J., additional, Alter, Galit, additional, Meiler, Jens, additional, Schey, Kevin L., additional, Julander, Justin G., additional, Diamond, Michael S., additional, and Crowe, James E., additional

Published
2021
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2. Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope

Author

Kim, Arthur S., primary, Kafai, Natasha M., additional, Winkler, Emma S., additional, Gilliland, Theron C., additional, Cottle, Emily L., additional, Earnest, James T., additional, Jethva, Prashant N., additional, Kaplonek, Paulina, additional, Shah, Aadit P., additional, Fong, Rachel H., additional, Davidson, Edgar, additional, Malonis, Ryan J., additional, Quiroz, Jose A., additional, Williamson, Lauren E., additional, Vang, Lo, additional, Mack, Matthias, additional, Crowe, James E., additional, Doranz, Benjamin J., additional, Lai, Jonathan R., additional, Alter, Galit, additional, Gross, Michael L., additional, Klimstra, William B., additional, Fremont, Daved H., additional, and Diamond, Michael S., additional

Published
2021
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3. Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Author

Suryadevara, Naveenchandra, primary, Shrihari, Swathi, additional, Gilchuk, Pavlo, additional, VanBlargan, Laura A., additional, Binshtein, Elad, additional, Zost, Seth J., additional, Nargi, Rachel S., additional, Sutton, Rachel E., additional, Winkler, Emma S., additional, Chen, Elaine C., additional, Fouch, Mallorie E., additional, Davidson, Edgar, additional, Doranz, Benjamin J., additional, Chen, Rita E., additional, Shi, Pei-Yong, additional, Carnahan, Robert H., additional, Thackray, Larissa B., additional, Diamond, Michael S., additional, and Crowe, James E., additional

Published
2021
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4. Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity

Author

Rucker, Joseph, Samson, Michel, Doranz, Benjamin J., Libert, Frederick, Berson, Joanne F., Yi, Yanjie, Smyth, Robert J., Collman, Ronald G., Broder, Christopher C., Vassart, Gilbert, Doms, Robert W., and Parmentier, Marc

Subjects
HIV infection -- Genetic aspects, Viruses -- Receptors, Membrane fusion -- Genetic aspects, Biological sciences
Abstract

The beta-chemokine receptors CCR5 and CCR2b are the cofactors for entry of M-tropic viruses into cells. Previous studies have reported that M-tropic trains are more sensitive to substitutions in the regions of CCR5 than CCR2b. To understand the molecular basis of CCR5 usage in viral tropism, chimeric molecules of both CCR5 and CCR2b were constructed and regions involved in cofactor utilization by HIV-1 strains were mapped. The chimeras showed that the amino terminus and the first extracellular loop of CCR5 contribute to enhancing the entry of HIV-1 cofactors into the cell.

Published
1996

5. A dual-tropic primary HIV-1 isolate that uses Fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors

Author

Doranz, Benjamin J., Rucker, Joseph, Yi, Yanjie, Smyth, Robert J., Samson, Michel, Peiper, Stephen C., Parmentier, Marc, Collman, Ronald G., and Doms, Robert W.

Subjects
HIV infection -- Research, Proteins -- Receptors, Gene fusion -- Research, Biological sciences
Abstract

HIV-1 isolate 89.6 uses Fusin and CKR-5 as entry cofactors indicating that the evolution from a M-tropic to T-tropic phenotype probably occurs due to changes in HIV-1 env that allow the use of dual cofactors. The beta-chemokine receptors CKR-3 and CHR-2b allow the formation of syncytia mediated by HIV-1 89.6 env proteins but fail to allow fusion by T-tropic and M-tropic strains. Expression of CKR-5 with CD4 allows nonpermissive cells to form syncytia with cells expressing M-tropic proteins. However, CKR-5 fails to allow entry of cells expressing T-tropic and HIV-1 env proteins.

Published
1996

6. Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

Author

Saphire, Erica Ollmann, primary, Schendel, Sharon L., additional, Fusco, Marnie L., additional, Gangavarapu, Karthik, additional, Gunn, Bronwyn M., additional, Wec, Anna Z., additional, Halfmann, Peter J., additional, Brannan, Jennifer M., additional, Herbert, Andrew S., additional, Qiu, Xiangguo, additional, Wagh, Kshitij, additional, He, Shihua, additional, Giorgi, Elena E., additional, Theiler, James, additional, Pommert, Kathleen B.J., additional, Krause, Tyler B., additional, Turner, Hannah L., additional, Murin, Charles D., additional, Pallesen, Jesper, additional, Davidson, Edgar, additional, Ahmed, Rafi, additional, Aman, M. Javad, additional, Bukreyev, Alexander, additional, Burton, Dennis R., additional, Crowe, James E., additional, Davis, Carl W., additional, Georgiou, George, additional, Krammer, Florian, additional, Kyratsous, Christos A., additional, Lai, Jonathan R., additional, Nykiforuk, Cory, additional, Pauly, Michael H., additional, Rijal, Pramila, additional, Takada, Ayato, additional, Townsend, Alain R., additional, Volchkov, Viktor, additional, Walker, Laura M., additional, Wang, Cheng-I., additional, Zeitlin, Larry, additional, Doranz, Benjamin J., additional, Ward, Andrew B., additional, Korber, Bette, additional, Kobinger, Gary P., additional, Andersen, Kristian G., additional, Kawaoka, Yoshihiro, additional, Alter, Galit, additional, Chandran, Kartik, additional, and Dye, John M., additional

Published
2018
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7. Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

Author

Zhao, Xuelian, primary, Howell, Katie A., additional, He, Shihua, additional, Brannan, Jennifer M., additional, Wec, Anna Z., additional, Davidson, Edgar, additional, Turner, Hannah L., additional, Chiang, Chi-I., additional, Lei, Lin, additional, Fels, J. Maximilian, additional, Vu, Hong, additional, Shulenin, Sergey, additional, Turonis, Ashley N., additional, Kuehne, Ana I., additional, Liu, Guodong, additional, Ta, Mi, additional, Wang, Yimeng, additional, Sundling, Christopher, additional, Xiao, Yongli, additional, Spence, Jennifer S., additional, Doranz, Benjamin J., additional, Holtsberg, Frederick W., additional, Ward, Andrew B., additional, Chandran, Kartik, additional, Dye, John M., additional, Qiu, Xiangguo, additional, Li, Yuxing, additional, and Aman, M. Javad, additional

Published
2017
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8. Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection

Author

Flyak, Andrew I., primary, Shen, Xiaoli, additional, Murin, Charles D., additional, Turner, Hannah L., additional, David, Joshua A., additional, Fusco, Marnie L., additional, Lampley, Rebecca, additional, Kose, Nurgun, additional, Ilinykh, Philipp A., additional, Kuzmina, Natalia, additional, Branchizio, Andre, additional, King, Hannah, additional, Brown, Leland, additional, Bryan, Christopher, additional, Davidson, Edgar, additional, Doranz, Benjamin J., additional, Slaughter, James C., additional, Sapparapu, Gopal, additional, Klages, Curtis, additional, Ksiazek, Thomas G., additional, Saphire, Erica Ollmann, additional, Ward, Andrew B., additional, Bukreyev, Alexander, additional, and Crowe, James E., additional

Published
2016
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9. Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress

Author

Fox, Julie M., primary, Long, Feng, additional, Edeling, Melissa A., additional, Lin, Hueylie, additional, van Duijl-Richter, Mareike K.S., additional, Fong, Rachel H., additional, Kahle, Kristen M., additional, Smit, Jolanda M., additional, Jin, Jing, additional, Simmons, Graham, additional, Doranz, Benjamin J., additional, Crowe, James E., additional, Fremont, Daved H., additional, Rossmann, Michael G., additional, and Diamond, Michael S., additional

Published
2015
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10. Regions in β-Chemokine Receptors CCR5 and CCR2b That Determine HIV-1 Cofactor Specificity

Author

Rucker, Joseph, primary, Samson, Michel, additional, Doranz, Benjamin J, additional, Libert, Frédérick, additional, Berson, Joanne F, additional, Yi, Yanjie, additional, Smyth, Robert J, additional, Collman, Ronald G, additional, Broder, Christopher C, additional, Vassart, Gilbert, additional, Doms, Robert W, additional, and Parmentier, Marc, additional

Published
1996
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