1. Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System
- Author
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Rüdiger Klein, Jeffrey T. Henderson, John C. Roder, Tracy M. Saxton, Mark Henkemeyer, Donata Orioli, and Tony Pawson
- Subjects
medicine.medical_specialty ,Receptor, EphB2 ,Gene Expression ,Ligands ,EPH receptor B2 ,General Biochemistry, Genetics and Molecular Biology ,Receptor tyrosine kinase ,Mice ,Prosencephalon ,EPH receptor A3 ,Internal medicine ,medicine ,Animals ,Ephrin ,Ephrin B3 ,Alleles ,Mammals ,biology ,Biochemistry, Genetics and Molecular Biology(all) ,Homozygote ,Erythropoietin-producing hepatocellular (Eph) receptor ,Membrane Proteins ,Receptor Protein-Tyrosine Kinases ,Optic Nerve ,beta-Galactosidase ,Immunohistochemistry ,Axons ,Cell biology ,Endocrinology ,Mutagenesis ,biology.protein ,Ephrin A5 ,Axon guidance - Abstract
Eph family receptor tyrosine kinases have been proposed to control axon guidance and fasciculation. To address the biological functions of the Eph family member Nuk, two mutations in the mouse germline have been generated: a protein null allele ( Nuk 1 ) and an allele that encodes a Nuk-βgal fusion receptor lacking the tyrosine kinase and C-terminal domains ( Nuk lacZ ). In Nuk 1 homozygous brains, the majority of axons forming the posterior tract of the anterior commissure migrate aberrantly to the floor of the brain, resulting in a failure of cortical neurons to link the two temporal lobes. These results indicate that Nuk, a receptor that binds transmembrane ligands, plays a critical and unique role in the pathfinding of specific axons in the mammalian central nervous system.
- Published
- 1996
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