1. Engrailed and hedgehog make the range of Wingless asymmetric in Drosophila embryos
- Author
-
Nora Fascetti, Jean-Paul Vincent, Cyrille Alexandre, and Bénédicte Sanson
- Subjects
animal structures ,Transcription, Genetic ,Wnt1 Protein ,Biology ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Proto-Oncogene Proteins ,Animals ,Drosophila Proteins ,Hedgehog Proteins ,Cloning, Molecular ,Hedgehog ,Psychological repression ,Transcription factor ,030304 developmental biology ,Genetics ,Homeodomain Proteins ,0303 health sciences ,integumentary system ,Biochemistry, Genetics and Molecular Biology(all) ,Rhomboid ,fungi ,Gene Expression Regulation, Developmental ,Membrane Proteins ,Embryonic stem cell ,engrailed ,Cell biology ,Naked cuticle ,Larva ,embryonic structures ,Insect Proteins ,Drosophila ,Epidermis ,030217 neurology & neurosurgery ,Drosophila Protein ,Signal Transduction ,Transcription Factors - Abstract
In many instances, remote signaling involves the transport of secreted molecules. Here, we examine the spread of Wingless within the embryonic epidermis of Drosophila. Using two assays for Wingless activity (specification of naked cuticle and repression of rhomboid transcription), we found that Wingless acts at a different range in the anterior and posterior directions. We show that this asymmetry follows in part from differential distribution of the Wingless protein. Transport or stability is reduced within engrailed-expressing cells, and farther posteriorward Wingless movement is blocked at the presumptive segment boundary and perhaps beyond. We demonstrate the role of hedgehog in the formation of this barrier.
- Published
- 1999