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16 results on '"Clish, Clary B"'

1. Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment

Author

Zhu, Meilin, Frank, Matthew W., Radka, Christopher D., Jeanfavre, Sarah, Xu, Jiawu, Tse, Megan W., Pacheco, Julian Avila, Kim, Jae Sun, Pierce, Kerry, Deik, Amy, Hussain, Fatima Aysha, Elsherbini, Joseph, Hussain, Salina, Xulu, Nondumiso, Khan, Nasreen, Pillay, Vanessa, Mitchell, Caroline M., Dong, Krista L., Ndung'u, Thumbi, Clish, Clary B., Rock, Charles O., Blainey, Paul C., Bloom, Seth M., and Kwon, Douglas S.

Published
2024
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3. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

Author

Rusu, Victor, Hoch, Eitan, Mercader, Josep M, Tenen, Danielle E, Gymrek, Melissa, Hartigan, Christina R, DeRan, Michael, von Grotthuss, Marcin, Fontanillas, Pierre, Spooner, Alexandra, Guzman, Gaelen, Deik, Amy A, Pierce, Kerry A, Dennis, Courtney, Clish, Clary B, Carr, Steven A, Wagner, Bridget K, Schenone, Monica, Ng, Maggie CY, Chen, Brian H, Consortium, MEDIA, Shriner, Daniel, Li, Jiang, Chen, Wei-Min, Guo, Xiuqing, Liu, Jiankang, Bielinski, Suzette J, Yanek, Lisa R, Nalls, Michael A, Comeau, Mary E, Rasmussen-Torvik, Laura J, Jensen, Richard A, Evans, Daniel S, Sun, Yan V, An, Ping, Patel, Sanjay R, Lu, Yingchang, Long, Jirong, Armstrong, Loren L, Wagenknecht, Lynne, Yang, Lingyao, Snively, Beverly M, Palmer, Nicholette D, Mudgal, Poorva, Langefeld, Carl D, Keene, Keith L, Freedman, Barry I, Mychaleckyj, Josyf C, Nayak, Uma, Raffel, Leslie J, Goodarzi, Mark O, Chen, Y-D Ida, Taylor, Herman A, Correa, Adolfo, Sims, Mario, Couper, David, Pankow, James S, Boerwinkle, Eric, Adeyemo, Adebowale, Doumatey, Ayo, Chen, Guanjie, Mathias, Rasika A, Vaidya, Dhananjay, Singleton, Andrew B, Zonderman, Alan B, Igo, Robert P, Sedor, John R, Consortium, the FIND, Kabagambe, Edmond K, Siscovick, David S, McKnight, Barbara, Rice, Kenneth, Liu, Yongmei, Hsueh, Wen-Chi, Zhao, Wei, Bielak, Lawrence F, Kraja, Aldi, Province, Michael A, Bottinger, Erwin P, Gottesman, Omri, Cai, Qiuyin, Zheng, Wei, Blot, William J, Lowe, William L, Pacheco, Jennifer A, Crawford, Dana C, Consortium, the eMERGE, Consortium, the DIAGRAM, Grundberg, Elin, Consortium, the MuTHER, Rich, Stephen S, Hayes, M Geoffrey, Shu, Xiao-Ou, Loos, Ruth JF, Borecki, Ingrid B, Peyser, Patricia A, Cummings, Steven R, and Psaty, Bruce M

Subjects
Biological Sciences, Genetics, Clinical Research, Diabetes, Digestive Diseases, Liver Disease, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Basigin, Cell Membrane, Chromosomes, Human, Pair 17, Diabetes Mellitus, Type 2, Gene Knockdown Techniques, Haplotypes, Hepatocytes, Heterozygote, Histone Code, Humans, Liver, Models, Molecular, Monocarboxylic Acid Transporters, MEDIA Consortium, SIGMA T2D Consortium, MCT11, SLC16A11, disease mechanism, fatty acid metabolism, genetics, lipid metabolism, monocarboxylates, precision medicine, solute carrier, type 2 diabetes, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapping, we define a set of tightly linked variants likely to contain the causal allele(s). We show that variants on the T2D-associated haplotype have two distinct effects: (1) decreasing SLC16A11 expression in liver and (2) disrupting a key interaction with basigin, thereby reducing cell-surface localization. Both independent mechanisms reduce SLC16A11 function and suggest SLC16A11 is the causal gene at this locus. To gain insight into how SLC16A11 disruption impacts T2D risk, we demonstrate that SLC16A11 is a proton-coupled monocarboxylate transporter and that genetic perturbation of SLC16A11 induces changes in fatty acid and lipid metabolism that are associated with increased T2D risk. Our findings suggest that increasing SLC16A11 function could be therapeutically beneficial for T2D. VIDEO ABSTRACT.

Published
2017

5. CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

Author

Wang, Chao, Yosef, Nir, Gaublomme, Jellert, Wu, Chuan, Lee, Youjin, Clish, Clary B., Kaminski, Jim, Xiao, Sheng, Zu Horste, Gerd Meyer, Pawlak, Mathias, Kishi, Yasuhiro, Joller, Nicole, Karwacz, Katarzyna, Zhu, Chen, Ordovas-Montanes, Maria, Madi, Asaf, Wortman, Ivo, Miyazaki, Toru, Sobel, Raymond A., Park, Hongkun, Regev, Aviv, and Kuchroo, Vijay K.

Published
2015
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6. Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism

Author

Vatanen, Tommi, primary, Jabbar, Karolina S., additional, Ruohtula, Terhi, additional, Honkanen, Jarno, additional, Avila-Pacheco, Julian, additional, Siljander, Heli, additional, Stražar, Martin, additional, Oikarinen, Sami, additional, Hyöty, Heikki, additional, Ilonen, Jorma, additional, Mitchell, Caroline M., additional, Yassour, Moran, additional, Virtanen, Suvi M., additional, Clish, Clary B., additional, Plichta, Damian R., additional, Vlamakis, Hera, additional, Knip, Mikael, additional, and Xavier, Ramnik J., additional

Published
2022
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7. A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning

Author

Vatanen, Tommi, primary, Ang, Qi Yan, additional, Siegwald, Léa, additional, Sarker, Shafiqul Alam, additional, Le Roy, Caroline I., additional, Duboux, Stéphane, additional, Delannoy-Bruno, Omar, additional, Ngom-Bru, Catherine, additional, Boulangé, Claire L., additional, Stražar, Martin, additional, Avila-Pacheco, Julian, additional, Deik, Amy, additional, Pierce, Kerry, additional, Bullock, Kevin, additional, Dennis, Courtney, additional, Sultana, Shamima, additional, Sayed, Sharika, additional, Rahman, Mahbubar, additional, Ahmed, Tahmeed, additional, Modesto, Monica, additional, Mattarelli, Paola, additional, Clish, Clary B., additional, Vlamakis, Hera, additional, Plichta, Damian R., additional, Sakwinska, Olga, additional, and Xavier, Ramnik J., additional

Published
2022
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8. Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise

Author

Sanford, James A., primary, Nogiec, Christopher D., additional, Lindholm, Malene E., additional, Adkins, Joshua N., additional, Amar, David, additional, Dasari, Surendra, additional, Drugan, Jonelle K., additional, Fernández, Facundo M., additional, Radom-Aizik, Shlomit, additional, Schenk, Simon, additional, Snyder, Michael P., additional, Tracy, Russell P., additional, Vanderboom, Patrick, additional, Trappe, Scott, additional, Walsh, Martin J., additional, Evans, Charles R., additional, Fernandez, Facundo M., additional, Li, Yafeng, additional, Sanford, James A., additional, Tomlinson, Lyl, additional, Lee Alekel, D., additional, Bekirov, Iddil, additional, Boyce, Amanda T., additional, Boyington, Josephine, additional, Fleg, Jerome L., additional, Joseph, Lyndon J.O., additional, Laughlin, Maren R., additional, Maruvada, Padma, additional, Morris, Stephanie A., additional, McGowan, Joan A., additional, Nierras, Concepcion, additional, Pai, Vinay, additional, Peterson, Charlotte, additional, Ramos, Ed, additional, Roary, Mary C., additional, Williams, John P., additional, Xia, Ashley, additional, Cornell, Elaine, additional, Rooney, Jessica, additional, Miller, Michael E., additional, Ambrosius, Walter T., additional, Rushing, Scott, additional, Stowe, Cynthia L., additional, Jack Rejeski, W., additional, Nicklas, Barbara J., additional, Pahor, Marco, additional, Lu, Ching-ju, additional, Trappe, Todd, additional, Chambers, Toby, additional, Raue, Ulrika, additional, Lester, Bridget, additional, Bergman, Bryan C., additional, Bessesen, David H., additional, Jankowski, Catherine M., additional, Kohrt, Wendy M., additional, Melanson, Edward L., additional, Moreau, Kerrie L., additional, Schauer, Irene E., additional, Schwartz, Robert S., additional, Kraus, William E., additional, Slentz, Cris A., additional, Huffman, Kim M., additional, Johnson, Johanna L., additional, Willis, Leslie H., additional, Kelly, Leslie, additional, Houmard, Joseph A., additional, Dubis, Gabriel, additional, Broskey, Nick, additional, Goodpaster, Bret H., additional, Sparks, Lauren M., additional, Coen, Paul M., additional, Cooper, Dan M., additional, Haddad, Fadia, additional, Rankinen, Tuomo, additional, Ravussin, Eric, additional, Johannsen, Neil, additional, Harris, Melissa, additional, Jakicic, John M., additional, Newman, Anne B., additional, Forman, Daniel D., additional, Kershaw, Erin, additional, Rogers, Renee J., additional, Nindl, Bradley C., additional, Page, Lindsay C., additional, Stefanovic-Racic, Maja, additional, Barr, Susan L., additional, Rasmussen, Blake B., additional, Moro, Tatiana, additional, Paddon-Jones, Doug, additional, Volpi, Elena, additional, Spratt, Heidi, additional, Musi, Nicolas, additional, Espinoza, Sara, additional, Patel, Darpan, additional, Serra, Monica, additional, Gelfond, Jonathan, additional, Burns, Aisling, additional, Bamman, Marcas M., additional, Buford, Thomas W., additional, Cutter, Gary R., additional, Bodine, Sue C., additional, Esser, Karyn, additional, Farrar, Rodger P., additional, Goodyear, Laurie J., additional, Hirshman, Michael F., additional, Albertson, Brent G., additional, Qian, Wei-Jun, additional, Piehowski, Paul, additional, Gritsenko, Marina A., additional, Monore, Matthew E., additional, Petyuk, Vladislav A., additional, McDermott, Jason E., additional, Hansen, Joshua N., additional, Hutchison, Chelsea, additional, Moore, Samuel, additional, Gaul, David A., additional, Clish, Clary B., additional, Avila-Pacheco, Julian, additional, Dennis, Courtney, additional, Kellis, Manolis, additional, Carr, Steve, additional, Jean-Beltran, Pierre M., additional, Keshishian, Hasmik, additional, Mani, D.R., additional, Clauser, Karl, additional, Krug, Karsten, additional, Mundorff, Charlie, additional, Pearce, Cadence, additional, Ivanova, Anna A., additional, Ortlund, Eric A., additional, Maner-Smith, Kristal, additional, Uppal, Karan, additional, Zhang, Tiantian, additional, Sealfon, Stuart C., additional, Zaslavsky, Elena, additional, Nair, Venugopalan, additional, Li, SiDe, additional, Jain, Nimisha, additional, Ge, YongChao, additional, Sun, Yifei, additional, Nudelman, German, additional, Ruf-zamojski, Frederique, additional, Smith, Gregory, additional, Pincas, Nhanna, additional, Rubenstein, Aliza, additional, Anne Amper, Mary, additional, Seenarine, Nitish, additional, Lappalainen, Tuuli, additional, Lanza, Ian R., additional, Sreekumaran Nair, K., additional, Klaus, Katherine, additional, Montgomery, Stephen B., additional, Smith, Kevin S., additional, Gay, Nicole R., additional, Zhao, Bingqing, additional, Hung, Chia-Jiu, additional, Zebarjadi, Navid, additional, Balliu, Brunilda, additional, Fresard, Laure, additional, Burant, Charles F., additional, Li, Jun Z., additional, Kachman, Maureen, additional, Soni, Tanu, additional, Raskind, Alexander B., additional, Gerszten, Robert, additional, Robbins, Jeremy, additional, Ilkayeva, Olga, additional, Muehlbauer, Michael J., additional, Newgard, Christopher B., additional, Ashley, Euan A., additional, Wheeler, Matthew T., additional, Jimenez-Morales, David, additional, Raja, Archana, additional, Dalton, Karen P., additional, Zhen, Jimmy, additional, Suk Kim, Young, additional, Christle, Jeffrey W., additional, Marwaha, Shruti, additional, Chin, Elizabeth T., additional, Hershman, Steven G., additional, Hastie, Trevor, additional, Tibshirani, Robert, additional, and Rivas, Manuel A., additional

Published
2020
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9. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Author

Chao, Chun-Cheih, primary, Gutiérrez-Vázquez, Cristina, additional, Rothhammer, Veit, additional, Mayo, Lior, additional, Wheeler, Michael A., additional, Tjon, Emily C., additional, Zandee, Stephanie E.J., additional, Blain, Manon, additional, de Lima, Kalil Alves, additional, Takenaka, Maisa C., additional, Avila-Pacheco, Julian, additional, Hewson, Patrick, additional, Liu, Lei, additional, Sanmarco, Liliana M., additional, Borucki, Davis M., additional, Lipof, Gabriel Z., additional, Trauger, Sunia A., additional, Clish, Clary B., additional, Antel, Jack P., additional, Prat, Alexandre, additional, and Quintana, Francisco J., additional

Published
2019
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10. Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles

Author

Werling, Kristine, primary, Shaw, W. Robert, additional, Itoe, Maurice A., additional, Westervelt, Kathleen A., additional, Marcenac, Perrine, additional, Paton, Douglas G., additional, Peng, Duo, additional, Singh, Naresh, additional, Smidler, Andrea L., additional, South, Adam, additional, Deik, Amy A., additional, Mancio-Silva, Liliana, additional, Demas, Allison R., additional, March, Sandra, additional, Calvo, Eric, additional, Bhatia, Sangeeta N., additional, Clish, Clary B., additional, and Catteruccia, Flaminia, additional

Published
2019
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11. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

Author

Sykes, David B., primary, Kfoury, Youmna S., additional, Mercier, François E., additional, Wawer, Mathias J., additional, Law, Jason M., additional, Haynes, Mark K., additional, Lewis, Timothy A., additional, Schajnovitz, Amir, additional, Jain, Esha, additional, Lee, Dongjun, additional, Meyer, Hanna, additional, Pierce, Kerry A., additional, Tolliday, Nicola J., additional, Waller, Anna, additional, Ferrara, Steven J., additional, Eheim, Ashley L., additional, Stoeckigt, Detlef, additional, Maxcy, Katrina L., additional, Cobert, Julien M., additional, Bachand, Jacqueline, additional, Szekely, Brian A., additional, Mukherjee, Siddhartha, additional, Sklar, Larry A., additional, Kotz, Joanne D., additional, Clish, Clary B., additional, Sadreyev, Ruslan I., additional, Clemons, Paul A., additional, Janzer, Andreas, additional, Schreiber, Stuart L., additional, and Scadden, David T., additional

Published
2016
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12. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

Author

Olenchock, Benjamin A., primary, Moslehi, Javid, additional, Baik, Alan H., additional, Davidson, Shawn M., additional, Williams, Jeremy, additional, Gibson, William J., additional, Chakraborty, Abhishek A., additional, Pierce, Kerry A., additional, Miller, Christine M., additional, Hanse, Eric A., additional, Kelekar, Ameeta, additional, Sullivan, Lucas B., additional, Wagers, Amy J., additional, Clish, Clary B., additional, Vander Heiden, Matthew G., additional, and Kaelin, William G., additional

Published
2016
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14. Regulation of Ferroptotic Cancer Cell Death by GPX4

Author

Yang, Wan Seok, primary, SriRamaratnam, Rohitha, additional, Welsch, Matthew E., additional, Shimada, Kenichi, additional, Skouta, Rachid, additional, Viswanathan, Vasanthi S., additional, Cheah, Jaime H., additional, Clemons, Paul A., additional, Shamji, Alykhan F., additional, Clish, Clary B., additional, Brown, Lewis M., additional, Girotti, Albert W., additional, Cornish, Virginia W., additional, Schreiber, Stuart L., additional, and Stockwell, Brent R., additional

Published
2014
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15. PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

Author

Israelsen, William J., primary, Dayton, Talya L., additional, Davidson, Shawn M., additional, Fiske, Brian P., additional, Hosios, Aaron M., additional, Bellinger, Gary, additional, Li, Jie, additional, Yu, Yimin, additional, Sasaki, Mika, additional, Horner, James W., additional, Burga, Laura N., additional, Xie, Jianxin, additional, Jurczak, Michael J., additional, DePinho, Ronald A., additional, Clish, Clary B., additional, Jacks, Tyler, additional, Kibbey, Richard G., additional, Wulf, Gerburg M., additional, Di Vizio, Dolores, additional, Mills, Gordon B., additional, Cantley, Lewis C., additional, and Vander Heiden, Matthew G., additional

Published
2013
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16. The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Author

Zhong, Lei, primary, D'Urso, Agustina, additional, Toiber, Debra, additional, Sebastian, Carlos, additional, Henry, Ryan E., additional, Vadysirisack, Douangsone D., additional, Guimaraes, Alexander, additional, Marinelli, Brett, additional, Wikstrom, Jakob D., additional, Nir, Tomer, additional, Clish, Clary B., additional, Vaitheesvaran, Bhavapriya, additional, Iliopoulos, Othon, additional, Kurland, Irwin, additional, Dor, Yuval, additional, Weissleder, Ralph, additional, Shirihai, Orian S., additional, Ellisen, Leif W., additional, Espinosa, Joaquin M., additional, and Mostoslavsky, Raul, additional

Published
2010
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